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A preparation method of multilamellar lipid vesicles wrapped with forskolin

A technology of forskolin and lipid vesicles, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of slow absorption, difficulty in oil mixing, large molecules, etc., and achieve vesicle Stable structure, increased stability and elasticity, good stability effect

Active Publication Date: 2018-12-07
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the active ingredients have large molecules and are not easy to mix with oils and absorb slowly.

Method used

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  • A preparation method of multilamellar lipid vesicles wrapped with forskolin
  • A preparation method of multilamellar lipid vesicles wrapped with forskolin

Examples

Experimental program
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Effect test

Embodiment 1

[0022] A preparation method of a multilamellar lipid vesicle wrapping forskolin, the steps are as follows:

[0023] 1) Weigh 10 g of forskolin and 20 g of propylene glycol, pre-mix and heat to 75°C, stir with a stirrer at low speed until completely dissolved;

[0024] 2) Weigh 8 g of polyglycerol-10 stearate, 10 g of glyceryl monostearate, and 2 g of glyceryl stearate citrate, mix them, heat to 75°C, stir with a stirrer at low speed, until completely dissolved;

[0025] 3) Weigh 5 g of hydrogenated lecithin Lecinol S-10, add 45 g of deionized water and mix evenly at low speed, keeping the temperature at 75 °C;

[0026] 4) Mix the forskolin alcohol dispersion, nonionic surfactant mixture and Lecinol S-10 aqueous solution obtained in steps 1, 2 and 3 with the assistance of 50 KHZ ultrasonic waves, and keep the ultrasonic temperature at 75 °C for 10 min. After cooling to room temperature and adding an appropriate amount of preservatives, forskolin-coated multilamellar lipid vesi...

Embodiment 2

[0036] A preparation method of a multilamellar lipid vesicle wrapping forskolin, the steps are as follows:

[0037] 1) Weigh 5 g of forskolin extract and 25 g of butanediol, pre-mix and heat to 70°C, stir with a stirrer at low speed until completely dissolved;

[0038] 2) Weigh 12 g of polyglycerol-10 stearate, 8 g of glyceryl monostearate, and 5 g of glyceryl stearate citrate, mix and heat to 70°C, stir with a mixer at low speed until completely dissolved;

[0039] 3) Weigh 10 g of hydrogenated lecithin Lecinol S-10, add 35 g of deionized water and mix evenly at low speed, keeping the temperature at 75 °C;

[0040] 4) Mix the forskolin alcohol dispersion, nonionic surfactant mixture and Lecinol S-10 aqueous solution obtained in steps 1, 2 and 3 with the assistance of 80 KHZ ultrasonic waves, and keep the ultrasonic temperature at 70 °C for 30 min. After cooling to room temperature and adding an appropriate amount of preservatives, forskolin-coated multilamellar lipid vesicles ...

Embodiment 3

[0043] A preparation method of a multilamellar lipid vesicle wrapping forskolin, the steps are as follows:

[0044] 1) Weigh 2 g of forskolin and 25 g of dipropylene glycol, pre-mix and heat to 80°C, stir with a stirrer at low speed until completely dissolved;

[0045] 2) Weigh 8 g of polyglycerol-10 stearate, 6 g of glyceryl monostearate, and 4 g of glyceryl stearate citrate, mix and heat to 80°C, stir with a stirrer at low speed until completely dissolved;

[0046] 3) Weigh 12 g of hydrogenated lecithin Lecinol S-10, add 43 g of deionized water and mix evenly at low speed, keeping the temperature at 80 °C;

[0047] 4) Mix the forskolin alcohol dispersion, nonionic surfactant mixture and Lecinol S-10 aqueous solution obtained in steps 4, 5 and 6 with the assistance of 100 KHZ ultrasonic waves, and keep the ultrasonic temperature at 80 °C for 5 min. After cooling to room temperature and adding an appropriate amount of preservatives, forskolin-coated multilamellar lipid vesicl...

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Abstract

The invention relates to a preparation method for multilayer lipid vesicles packaging forskolin. The preparation method is characterized by including the steps of 1), weighing the forskolin and water-soluble alcohol prior to mixing to obtain forskolin alcohol dispersion liquid; 2), weighing polyglycerol-10 stearate, glycerin monostearate and glyceryl stearate citrate prior to mixing to obtain a nonionic surfactant mixture; 3), weighing 10-30% of the forskolin alcohol dispersion liquid, 1-25% of the nonionic surfactant mixture, 0.5-12% of hydrogenated lecithin and deionized water; 4), dissolving the hydrogenated lecithin in the deionized water to obtain a hydrogenated lecithin water solution; 5), under the assistance of 50-100 KHZ (kilohertz) ultrasonic wave, adding the nonionic surfactant mixture and the hydrogenated lecithin water solution into the forskolin alcohol dispersion liquid, controlling the ultrasonic temperature to be 70-80DEGC, maintaining for 5-30 minutes, and cooling to obtain the multilayer lipid vesicles packaging the forskolin. With the method, charge capacity of the forskolin can be increased, and stability of the forskolin can be improved.

Description

technical field [0001] The invention relates to a preparation method of a multilamellar lipid vesicle wrapped with forskolin, which can be applied to the field of cosmetics. Background technique [0002] With the global "weight loss" craze setting off, cosmetics with slimming effects are becoming more and more popular. Forskolin is the only known plant-derived pure natural active ingredient that directly activates adenylate cyclase. After adenylate cyclase is activated, it can increase the concentration of cyclic adenosine monophosphate, thereby increasing the activity of hormone-sensitive esterase and accelerating fat decomposition. On the other hand, forskolin can stimulate the activation of thyroxine, increase the body's metabolic rate, and burn off excess body fat. Therefore, as a functional active substance in cosmetics, forskolin can reduce local fat accumulation through external application, and has a good application prospect in slimming cosmetics. [0003] Human ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/49A61K8/14A61K8/55A61K8/34A61Q19/00A61P3/04
CPCA61K8/14A61K8/34A61K8/345A61K8/498A61K8/553A61K2800/596A61Q19/00
Inventor 晏青陈玉燕孟麟涛许亚如曹建娣杜正芳蒋丽刚
Owner PROYA COSMETICS
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