Novel plasma purification system and application thereof

Abstract

The invention relates to a novel plasma purification system. The novel plasma purification system comprises a specific ligand-1 (immunoadsorbent) (1), a tissue compatibility carrier (3), a ligand-2 (2) and a plasma purification device. The specific ligand-1 still keeps the immunological activity, part of the ligand-1 is embedded into the surface of the carrier, the ligand-1 can be specifically combined with specific pathogenic factors (antibodies) in blood, therefore, a large quantity of the pathogenic factors keep a combined state, and only a few of pathogenic substances are dispersed in plasma in a free state. Carrier protein and the pathogenic factors are together removed regularly by specifically combining the plasma purification device with the ligand-2. According to the novel plasma purification system, the pathogenic factors in the blood can be specifically combined to enable the pathogenic factors to be in the combined state, therefore, the free-state pathogenic factors keep a low-concentration state for a long term, the tissue involvement degree is decreased, an 'immune storm' in a body is interrupted, the plasma purification frequency of a patient is decreased, and the complication incidence rate is decreased.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a novel plasma purification system and its application. Background technique [0002] Plasma purification therapy mainly refers to the removal of a large number of pathogenic substances in plasma in a short period of time, improving the clinical symptoms of patients, so as to achieve the purpose of treating diseases. At present, many technologies for selective filtration or adsorption removal of different pathogenic substances have been developed on this basis, including plasma exchange, double-filtration plasmapheresis (DFPP), cold filtration, thermal Filtration method, heparin-induced LDL precipitation method, plasma adsorption technology (plasmaabsorption, PA) and so on. The scope of technology application has also been expanded to hundreds of diseases in various systems. Patients with rheumatic immune diseases often have a variety of autoantibodies, complements, immune com...

AI Technical Summary

Problems solved by technology

Therefore, such patients need long-term and regular plasma purification to ensure that the pathogenic factors are cleaned up in time. In addition, plasma purification therapy requires a lot of fresh plasma, high frequency, high price, and many complications: hypotension, allergic reactions, hemolysis, Hypertension, arrhythmia, etc.

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