A kind of targeted drug-loaded nano-scale ultrasonic microbubble and preparation method thereof
A technology of drug-loaded nano and ultrasonic microbubbles, which is applied in pharmaceutical formulations, echo/ultrasonic imaging agents, anti-tumor drugs, etc., can solve the problems of single function, low sensitivity, clarity and accuracy, and overcome the problem of single function Effect
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specific Embodiment approach 1
[0018] Specific embodiment 1: A targeted drug-loaded nanoscale ultrasonic microbubble includes: microbubble membrane wall, FA-CNTs-PTX targeted drug-loaded complex, and inert gas wrapped inside the microbubble membrane wall; wherein the FA is folic acid, CNTs is carbon nanotubes, and PTX is paclitaxel;
[0019] The carbon nanotubes are placed inside the microbubble membrane wall, one end of the targeting factor folic acid is connected to the carbon nanotubes through chitosan, and the other end passes through the microbubble membrane wall to the outside of the microbubble membrane wall, and the carbon nanotubes connected to the folic acid The tubes were loaded with the antineoplastic drug paclitaxel by physical adsorption.
specific Embodiment approach 2
[0020] Embodiment 2: This embodiment differs from Embodiment 1 in that: the microbubble membrane wall is a lipid bilayer structure, and the microbubble membrane wall materials are Span60 and PEG1500.
[0021] Other steps and parameters are the same as those in Embodiment 1.
specific Embodiment approach 3
[0022] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: the particle size of the targeted drug-loaded nano-scale ultrasonic microbubbles is 400-600 nm.
[0023] Other steps and parameters are the same as those in Embodiment 1 or Embodiment 2.
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