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Application of a serum glycoprotein marker for autism

A glycoprotein, autism technology, applied in the application field of autism serum glycoprotein markers

Active Publication Date: 2017-10-20
广东侨都汇医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, only EEG, CT, and MR are available as auxiliary tests for the diagnosis of autism, and there are no reports on serum protein markers.

Method used

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  • Application of a serum glycoprotein marker for autism
  • Application of a serum glycoprotein marker for autism
  • Application of a serum glycoprotein marker for autism

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Experimental program
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Embodiment Construction

[0028] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0029] 1. Collection of samples

[0030] Sera from 65 children with confirmed ASD and 65 normal controls were collected from Xi'an Children's Hospital, the First Affiliated Hospital and the Second Affiliated Hospital of Xi'an Jiaotong University. Among them, 50 cases were used for the detection of lectin chips, and 15 cases were used for verification experiments. The drawn blood was allowed to stand at room temperature for 25 minutes, centrifuged at 1500g for 10 minutes, and the supernatant was collected and stored in a -80°C refrigerator until the time of detection.

[0031] 2. Lectin chip detection and sample analysis

[0032] The sera of 50 cases of ASD and 50 cases of TD were randomly divided into groups of 10 cases, and each group was divided into ASD-1, ASD-2, ASD-3, ASD-4, ASD-5 and ...

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Abstract

The invention discloses use of an autism seroglycoid marker. High-expression Apolipoprotein D (APOD) in ASD (Autism Spectrum Disorders) serum is simultaneously verified in agglutinin chip combined protein mass spectrometry forward verification and agglutinin / sugar-antibody chip reverse verification manners, and the APOD can serve as a seroglycoid marker for autism diagnosis, According to the use, vacancies in biochemical diagnosis on autism are made up.

Description

technical field [0001] The invention belongs to the field of autism serum marker detection, and relates to the application of autism serum glycoprotein marker, in particular to the application of glycoprotein Apolipoprotein D (APOD) as autism detection marker. Background technique [0002] Autism Spectrum Disorders (ASD) is a generalized developmental disorder caused by congenital brain function impairment, characterized by social interaction impairment, verbal and nonverbal communication deficits, narrow interests and stereotyped behavior etc. as the main clinical features. The disorder was first reported in 1943, but it was classified as "schizophrenia, child type". It was not until 1980 that this disorder was separated from childhood psychosis, and the concept and classification of general developmental disorders were proposed. Autism is one of its subtypes, and the classification status of autism in children has been confirmed. Therefore, autism in children as an indepe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/96G01N33/68
CPCG01N33/68G01N33/96
Inventor 黄辰秦棪楠刘利英陈艳妮
Owner 广东侨都汇医疗科技有限公司
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