Preparation method of calcium alginate microspheres with core-shell structure

Abstract

The invention provides a preparation method of calcium alginate microspheres with a core-shell structure, and relates to a preparation method of polymer microspheres. The preparation method comprises the steps that firstly, 100 parts of a polyvinyl alcohol solution (10%) and 10-100 parts of a sodium alginate solution (0.1%-10%) are mixed to prepare a uniform mixed solution; secondly, 1-200 parts of load materials are stirred and added into the mixed solution until a uniform mixture is prepared; thirdly, the mixture is continuously and dropwise added into a borax aqueous solution with the concentration of 0.1%-10%, and microspheres with the diameter of 0.4-4 mm can be formed; finally, the microspheres are taken out to be added into a calcium chloride solution with the concentration of 1%-10% under the stirring condition, so that calcium alginate wrapping layers can be formed on the surfaces of the microspheres, and then the calcium alginate microspheres with the core-shell structure can be obtained. According to the preparation method, the calcium alginate microspheres with the core-shell structure and the good permeability, gelling property and biocompatibility are prepared, have the mechanical strength and are suitable for fields of industry, agriculture, biology, medical science and the like.

Description

technical field [0001] The invention relates to a method for preparing polymer microspheres, in particular to a method for preparing calcium alginate microspheres with a core-shell structure. Background technique [0002] Polymer microsphere is a kind of geometric body whose size is distributed in micrometer and nanometer scale and whose shape is spherical or spheroidal. Because of its large surface area, high load capacity, controllable geometric size and biocompatibility, it has shown good performance in many high-tech fields such as biomedical engineering, immune testing, electronic information industry, high performance liquid chromatography, and catalysis. application prospects. [0003] Polymer microspheres are mainly divided into three categories: natural polymer microspheres, such as gelatin, chitosan, protein, starch and other matrices; semi-synthetic polymer microspheres, such as carboxymethyl cellulose, cellulose acetate succinate, etc. ; Synthetic polymer micro...

AI Technical Summary

Problems solved by technology

However, the traditional preparation method of self-assembled hollow microspheres is relatively complicated, and most of the materials used have poor biocompatibility and difficult to degrade. These unfavorable factors limit their development in biomedicine and other application fields.