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Ginsenoside Rb1 and Rd combination and application thereof to preparation of medicine for treating photoreceptor cell death related diseases

A technology of ginsenosides and photoreceptors, applied in sensory diseases, metabolic diseases, drug combinations, etc.

Active Publication Date: 2016-11-09
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing literature has not reported the combination of ginsenoside Rb1 and Rd in the treatment of diseases with photoreceptor cell death, retinal pigment epithelium and photoreceptor cell oxidative stress as the core pathology, including age-related macular degeneration, retinitis pigmentosa, Stargardt disease, etc. Pharmacological activity in retinal degenerative diseases such as cone-rod cell dystrophy and diabetic retinopathy

Method used

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  • Ginsenoside Rb1 and Rd combination and application thereof to preparation of medicine for treating photoreceptor cell death related diseases
  • Ginsenoside Rb1 and Rd combination and application thereof to preparation of medicine for treating photoreceptor cell death related diseases
  • Ginsenoside Rb1 and Rd combination and application thereof to preparation of medicine for treating photoreceptor cell death related diseases

Examples

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Effect test

Embodiment

[0043] In this example, the intervention effect of the combination of ginsenoside Rb1 and Rd on the retinal light-damaged mouse model was clarified through non-invasive retinal fundus tomography OCT technology, pathology and immunohistochemistry research methods. The results of the study showed that the combination of ginsenoside Rb1 and Rd can effectively interfere with the death of photoreceptor cells and the occurrence of retinal degeneration, and play a significant protective effect on the structure of the retina.

[0044] 1. Method

[0045] 1. Drugs

[0046] Ginsenoside Rb1 and Ginsenoside Rd. Ginsenoside Rb1 was purchased from Shanghai Yuanye Biotechnology Co., Ltd., 41753-43-9, Lot#H02J6X4, with a purity of ≥98%. Ginsenoside Rd was purchased from Shanghai Yuanye Biotechnology Co., Ltd., 52705-93-8, Lot#H02J6X2, with a purity of ≥98%.

[0047] 2. Animal models

[0048] 4-6 weeks old female Balb / c mice (Slack, Shanghai) were used for the experiment. The mice were ran...

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Abstract

The invention relates to application of a ginsenoside Rb1 and Rd combination to preparation of a medicine for treating photoreceptor cell death related diseases. A mouse model suffering from retinal light damage is adopted to simulate the common key pathological links in the process of various degenerative retinal diseases so as to research the intervention effects of the ginsenoside Rb1 and Rd combination on the mouse model suffering from retinal light damage, and the results show that the medicinal combination can maintain the format of the retina outer nuclear layer, effectively prevent the retina outer nuclear layer from degenerative damage and thickness reduction, inhibit death of photoreceptor cells, block oxidative stress of retinal pigment epitheliums and photoreceptor cells, effectively inhibit retinal damage related immuno-inflammatory responses and remarkably improve the degenerative retinal diseases. Therefore, the ginsenoside Rb1 and Rd combination can be used for preparing the medicine for treating various degenerative retinal diseases including age-related macular degeneration, retinal pigment degeneration, Stargardt disease, cone-rod cell dystrophy, diabetic retinopathy and the like.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to the preparation and treatment of the combination of ginsenoside Rb1 and Rd in the treatment of age-related macular degeneration, Stargardt, etc. Retinal degenerative diseases including retinal degeneration, cone-rod dystrophy, retinitis pigmentosa and diabetic retinopathy. Background technique [0002] Retinal degenerative diseases are a group of fundus diseases with oxidative stress and death of retinal photoreceptor cells and oxidative stress of retinal pigment epithelial cells as the core pathological changes, which can cause visual impairment or even blindness, including age-related macular degeneration, Stargardt disease, cone-rod dystrophy, retinitis pigmentosa, etc. In addition, excessive oxidative stress of photoreceptor cells is an important early pathological link in the occurrence of diabetic retinopathy. Treatment against photoreceptor cell death, retinal p...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P27/02A61P3/10A61P29/00A61P37/02
CPCA61K31/704A61K2300/00
Inventor 陈瑜张腾卞敏娟崔金刚王培伟于心同李黎杜宵烨丁李立强
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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