Transdermal iontophoresis administration apparatus and administration method based on metallic porous micro needle arrays

Abstract

The invention relates to a transdermal iontophoresis administration apparatus and an administration method based on metallic porous micro needle arrays. In the apparatus, a first metallic porous micro needle array is connected with an anode of a medical physiological electrode through welding, a second metallic porous micro needle array is connected with a cathode of the medical physiological electrode through welding, and the first metallic porous micro needle array is not connected with the second metallic porous micro needle array. The anode and cathode of the medical physiological electrode are correspondingly connected with a controllable pulse power supply. The micro needle arrays penetrate skin and damage cuticle tissue structure, holes of the micro needle arrays provide administration channels for liquid medicaments, and two ends of the micro needle arrays are powered up. Medicine can permeate into a human body under the effects of electric fields and electroosmotic flow.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, and more specifically, to a transdermal electroosmotic drug delivery device based on a metal porous microneedle array and a transdermal electroosmotic drug delivery method based on a metal porous microneedle array. Background technique [0002] With the development of society and the improvement of science and technology, more and more people pay attention to medical and health issues. Among the treatment methods at this stage, drug therapy is the most common treatment method. Its therapeutic principle is to transfer the drug from the outside of the body to the human body through a certain transport method to produce the drug effect. [0003] Injection is the most direct way of drug delivery in drug therapy, but the pain brought by injection to patients will affect the progress of treatment, and injection cannot achieve the effect of sustained release, which will cause blood drug ...

AI Technical Summary

Problems solved by technology

[0006] Although the microneedle array transdermal drug delivery technology has a good prospect, the microneedle array transdermal drug delivery technology is still immature, which is determined by the manufacturing process and structure of the microneedle array itself.

Common microneedle arrays can be divided into solid needles and hollow needles. Solid needles have good mechanical properties and can puncture the skin. However, due to their structural limitations, drugs need to be smeared after puncture during the administration process. Not only the operation is complicated but also the rate of administration is uncontrollable

Hollow needles can be used for microneedle injection, but the mechanical properties are slightly insufficient

In recent years, the introduction of the concept of degradable microneedles has brought new ideas for transdermal drug delivery. Degradable microneedles can degrade autonomously during the drug delivery process and can load more drugs, but the mechanical properties are insufficient and cannot be achieved. Controlled drug release rate is still a difficult problem that researchers need to overcome at this stage

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