Method and system for measuring depth resolution attenuation coefficient of sample based on OCT

Abstract

The invention discloses a method and a system for measuring the depth resolution attenuation coefficient of a sample based on OCT. According to the rule that the attenuation coefficient is different due to the fact that the concentration of the particle is different, the internal microstructure of medium space can be imaged by measuring the optical attenuation coefficient of the resolution of the medium space. Near-infrared laser beams adopt the single-time scattering manner when passing by a sample shallow layer area, and adopt the multi-time scattering manner when passing by a deep area. According to the method and the system, a single-time scattering model for depth resolution is adopted for measuring the scattering coefficient of the sample shallow layer area, and the scattering coefficient of the sample deep area is measured by adopting a multi-time scattering model based on the extended Huygens-Fresnel principle and combining with a segmentation fitting technology. Interference spectrum signals collected from the OCT system are subjected to data processing, the strength data of the OCT can be correspondingly converted into shallow layer and deep layer attenuation coefficient data, the reconstructed shallow layer high-spatial-resolution scattering coefficient image and deep layer high-measurement-accuracy scattering coefficient image are spliced, and the high-resolution and high-measurement-accuracy attenuation coefficient imaging of the sample can be realized.

Description

technical field [0001] The invention relates to optical coherence tomography technology, in particular to a method and system for measuring depth-resolution attenuation coefficients of samples based on OCT. Background technique [0002] Optical coherence tomography (OCT) is an emerging biomedical optical imaging technology, which can realize non-contact, non-damaging, high-resolution imaging of the structure and physiological functions of biological tissues, and can be used in the early stages of diseases. It has broad application prospects in the field of detection and in vivo biopsy. As an important method to provide clinical medical disease diagnosis and display guidance, the measurement of optical properties of biological tissues such as scattering coefficient, attenuation coefficient, absorption coefficient and anisotropy factor plays an important role in biophotonics research. The optical properties of biological tissue are related to various physiological states of t...

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Problems solved by technology

[0004] As the imaging depth increases, the light returned from the deep layer of the sample is dominated by multiple scattering, while the single scattering model is used to measure the inaccurate scattering coefficient of the deep layer of the sample, resulting in a decrease in imaging contrast

Therefore, methods that apply single-scattering models will be limited for measuring scattering coefficients in highly scattering media or deep layers of samples

The application of the traditional multiple scattering model is based on the extended Huygens-Fresnel principle, combined with segmental fitting, which can increase the imaging contrast of the deep layer of the sample, but segmental fitting is required in the entire imaging depth range, and the reconstructed scattering Coefficient image resolution is low

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