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High-selectivity quick fluorine ion analyzing colorimetric fluorescent probe

A hydrogen atom and compound technology, which is applied in the field of naphthalimide compounds as fluoride ion fluorescent probes, can solve problems such as difficulty in fluoride ion detection, and achieve good stability and simple synthesis

Inactive Publication Date: 2016-10-05
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The appropriate concentration of fluoride ions in drinking water is 0.5-1.0mg / L, which brings great difficulties to the detection of fluoride ions. Therefore, it is necessary to develop analytical methods that can detect fluoride ions in living bodies with high sensitivity.

Method used

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  • High-selectivity quick fluorine ion analyzing colorimetric fluorescent probe
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  • High-selectivity quick fluorine ion analyzing colorimetric fluorescent probe

Examples

Experimental program
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Effect test

Embodiment 1

[0033]

[0034] (Scheme 1) Dissolve 283mg (1mmol) of azetyl-4-hydrazine-1,8-naphthalene dicarboxamide in 15mL of absolute ethanol, then add 173mg (1mmol) of p-hydroxybenzaldehyde to reflux for 6h, and then use a high-pressure pump to Carry out suction filtration, obtain filter cake, filter cake becomes our crude product. If you want to get a purer product, you can recrystallize the filter cake with a mixed system of dichloromethane and petroleum ether (for example, v / v, 1:5) to get a pure product. 321.2 mg of pure orange product was obtained with a yield of 82%.

[0035] (Scheme 2) Dissolve 283mg (1mmol) of azetyl-4-hydrazine-1,8-naphthalene dicarboxamide in 15mL of absolute ethanol, then add 224.9mg (1.3mmol) of p-hydroxybenzaldehyde to reflux for 6h, and then use The high-pressure pump performs suction filtration to obtain a filter cake, which becomes our crude product. If you want to get a purer product, you can recrystallize the filter cake with a mixed system of dich...

Embodiment 2

[0041] Figure 1(a) is the probe (10μM) added to F - Fluorescence spectra before and after (400μM), through the illustration we can see that the fluorescence changes are very obvious.

[0042] Figure 1(b) is the probe (10 μM) added to F - (400μM) before and after the absorption spectrum, we can clearly see the change of the absorption spectrum through the illustration, and through the change of color, it can be observed with the naked eye.

Embodiment 3

[0044] Figure 2a Different concentrations of F - (0-500μM) on the probe (10μM) fluorescence spectrum; Figure 2b Different concentrations of F - (0-500μM) to probe (10μM) ultraviolet absorption spectrum; Figure 2c Different concentrations of F - (0-60μM) vs probe (10μM) A 596 / A 476 satisfy a good linear relationship.

[0045] It can be seen that with the F in the probe solution - As the concentration increases, the fluorescence intensity gradually weakens, and at (0-60μM) F - Concentration range, F - concentration and A 596 / A 476 into a linear relationship. The appropriate concentration of fluoride ions in drinking water is 0.5-1.0 mg / L. Therefore, the probe of the present invention can more accurately determine the content of fluoride ions in the sample to be tested.

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Abstract

The invention relates to a high-selectivity quick fluorine ion analyzing colorimetric fluorescent probe. Specifically, the colorimetric fluorescent probe is a naphthalimide compound which can serve as the fluorine ion colorimetric fluorescent probe for fluorine ion detection. The probe has at least one of advantages including high selectivity in fluorine ion recognition, quickness in response to fluorine ions, high sensitivity in fluorine ion analysis, property stability, availability for long-term storage and high antijamming capability.

Description

technical field [0001] The invention relates to a naphthalimide compound used as a fluoride ion fluorescent probe, which can rapidly and sensitively recognize the fluoride ion with high selectivity, or it can measure the concentration of the fluoride ion in a sample. Background technique [0002] Fluorine is one of the important trace elements in the human body. Fluoride is closely related to human life activities and metabolism of teeth and bone tissue. A small amount of fluorine is conducive to the normal development of teeth, can promote the resistance of tooth enamel to bacterial acid corrosion, and prevent dental caries. Therefore, water treatment plants generally add a small amount of fluorine to tap water and drinking water. At the same time, fluoride is very helpful to the health of bones, especially the prevention of osteoporosis. The imbalance of fluoride ions in the human body will cause serious harm to the body, and the lack of fluoride in the teeth will lead to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D221/14C09K11/06G01N21/64G01N21/33G01N21/78
CPCC07D221/14C09K11/06C09K2211/1029G01N21/33G01N21/643G01N21/78
Inventor 舒伟柳彩云朱宝存唐成城王作凯王雅伟
Owner UNIV OF JINAN
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