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Preparation method of high-viscoelasticity injection composed of glucosamine and sodium hyaluronate

A technology of glucosamine and sodium hyaluronate, which is applied in the field of medicine and can solve the problems of many improvement reactions and ineffective effects

Inactive Publication Date: 2016-10-05
上海建华精细生物制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The glucosamine currently on the market is mainly divided into glucosamine hydrochloride and glucosamine sulfate. In clinical trials in China, glucosamine sulfate and hydrochloride have similar therapeutic effects, but in terms of side effects on the body, amino Glucose hydrochloride group has more physical discomfort, mainly manifested in stomach pain, many improvement reactions, and the effect is relatively inconspicuous

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Glucosamine Sulfate Sodium Salt 4.2g

[0043] Sodium Hyaluronate 13.5g

[0044] Sodium dihydrogen phosphate 0.9g

[0045] Disodium hydrogen phosphate 0.6g

[0046] Sodium chloride 10.8g

[0047] water 300ml

[0048] Its preparation method is characterized in that its preparation steps are:

[0049] (1) Pass each raw and auxiliary material through an 80-mesh sieve and pulverize it for later use;

[0050] (2) Precisely weigh 0.9g of sodium dihydrogen phosphate, 0.6g of disodium hydrogen phosphate, and 10.8g of sodium chloride into 400ml of sterilized water, stir to dissolve completely, and prepare phosphate buffer;

[0051] (3) The buffer solution is sterilized by filtration through a 0.22mm microporous membrane, and 300ml of the filtered sterile buffer solution is used for later use;

[0052] (4) Accurately weigh 4.2g of glucosamine sulfate sodium chloride double salt and 13.5g of sodium hyaluronate, and add them to the filtered phosphate buffer;

[0053] (5) Place ...

Embodiment 2

[0056] Glucosamine Sulfate Sodium Salt 4.2g

[0057] Sodium Hyaluronate 13.5g

[0058] Sodium dihydrogen phosphate 0.9g

[0059] Disodium hydrogen phosphate 0.6g

[0060] Sodium chloride 11.0g

[0061] water 300ml

[0062] Its preparation method is characterized in that its preparation steps are:

[0063] (1) Pass each raw and auxiliary material through an 80-mesh sieve and pulverize it for later use;

[0064] (2) Precisely weigh 0.9g sodium dihydrogen phosphate, 0.6g disodium hydrogen phosphate, 11.0g sodium chloride into 400ml sterilized water, stir to dissolve completely, and prepare phosphate buffer;

[0065] (3) The buffer solution is sterilized by filtration through a 0.22mm microporous membrane, and 300ml of the filtered sterile buffer solution is used for later use;

[0066] (4) Accurately weigh 4.2g of glucosamine sulfate sodium chloride double salt and 13.5g of sodium hyaluronate, and add them to the filtered phosphate buffer;

[0067] (5) Place on a shaker an...

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Abstract

The invention relates to a preparation method of a high-viscoelasticity injection composed of glucosamine and sodium hyaluronate. The injection mainly includes the components of glucosamine sulfate / sodium chloride double salt and the sodium hyaluronate with sodium dihydrogen phosphate and disodium hydrogen phosphate, as auxiliary materials, being used as a pH regulator. Sodium chloride is employed as an osmotic pressure regulator. The injection is greatly reduced in hygroscopicity and enhanced in flowability, is improved in stability, has good treatment effects, low drug resistance rate and less adverse reaction, and can be used in intra-articular injection therapy on arthritis.

Description

technical field [0001] The invention relates to a preparation method of a high-viscosity injection combined with glucosamine and sodium hyaluronate, provides a pharmaceutical composition for intra-articular injection, and belongs to the technical field of medicine. Background technique [0002] Osteoarthritis is a chronic joint disease characterized by degeneration of articular cartilage and secondary bone hyperplasia. More common in middle-aged and elderly people, more women than men. It tends to occur in the knee joints, hip joints, lumbosacral spinal joints, and first metatarsophalangeal joints with heavy loads, as well as the distal interphalangeal joints and proximal interphalangeal joints of the hands. The disease is also known as osteoarthritis, degenerative arthritis, proliferative arthritis, degenerative arthritis, osteoarthritis, etc. As the population ages and rates of obesity rise, the prevalence of osteoarthritis will increase. [0003] Osteoarthritis can sta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/728A61K9/08A61K47/02A61P19/02A61K31/7008
Inventor 刘志雯黄慧娟张军东吴剑英
Owner 上海建华精细生物制品有限公司
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