Developing agent applied to tumor radiology department

A technology of tumor radiation and contrast agent, which is applied in the field of contrast agent in the Department of Oncology Radiology, which can solve the problems of large background noise, short effective observation time of resonance imaging, and poor image contrast quality, so as to reduce background noise and improve image contrast quality , the effect of small particle size

Inactive Publication Date: 2016-09-28
曹炳龙
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Among these methods, nuclear magnetic resonance has incomparable advantages compared with radioactive isotopes, but the background

Method used

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Embodiment 1

[0015] The present invention proposes a contrast agent for use in oncology radiology. Its raw materials include, in parts by weight, 2 parts of citric acid buffer solution of the contrast agent Omniscan, 50 parts of chloroform, 1 part of dimethyl sulfoxide, and 100 parts of soybean lecithin, 2 parts of dilauroyl lecithin, 3 parts of dipalmitoyl lecithin, 1 part of cholesterol, 12 parts of PEG3000, 1 part of palmitic acid PEG3000 monoester, 1 part of palmitic acid-GG peptide.

Embodiment 2

[0017] The present invention proposes a contrast agent for use in oncology radiology. Its raw materials include by weight: 12 parts of citric acid buffer solution of the contrast agent Omniscan, 20 parts of chloroform, 2 parts of dimethyl sulfoxide, 30 parts of soybean lecithin, 10 parts of dilauroyl lecithin, 1 part of dipalmitoyl lecithin, 10 parts of cholesterol, 2 parts of PEG3000, 4 parts of palmitic acid PEG3000 monoester, and 0.5 part of palmitic acid-GG peptide.

Embodiment 3

[0019] The present invention proposes a contrast agent applied to the oncology radiology department, and its raw materials include by weight: 4 parts of citric acid buffer solution of the contrast agent Omniscan, 40 parts of chloroform, 1.2 parts of dimethyl sulfoxide, 80 parts of soybean lecithin, 4 parts of dilauroyl lecithin, 2.5 parts of dipalmitoyl lecithin, 2 parts of cholesterol, 10 parts of PEG3000, 2 parts of palmitic acid PEG3000 monoester, and 0.8 part of palmitic acid-GG peptide.

[0020] In the citric acid buffer solution of the developer Omniscan, the pH of the developer Omniscan is 5.2, and the concentration of the gadolinium chelate is 18 mg / mL.

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Abstract

The invention discloses a contrast agent used in the tumor radiology department. The raw materials include: 2-12 parts of citric acid buffer solution of the contrast agent Omniscan, 20-50 parts of chloroform, and 1-2 parts of dimethyl sulfoxide in parts by weight. , soybean lecithin 30‑100 parts, dilauroyl lecithin 2‑10 parts, dipalmitoyl lecithin 1‑3 parts, cholesterol 1‑10 parts, PEG3000 2‑12 parts, palmitic acid PEG3000 monoester 1‑4 parts, Palmitic acid‑GG peptide 0.5‑1 part. The developer obtained by the invention can significantly reduce the background noise during magnetic resonance imaging, improve the image contrast quality, not only can detect early tumors, but also make the effective observation time of magnetic resonance imaging more than 2 hours.

Description

technical field [0001] The present invention relates to the technical field of imaging agents, in particular to a imaging agent used in oncology radiology. Background technique [0002] The reliable way to cure the tumor lies in early detection and early treatment. At present, tumor screening measures mainly use imaging and ultrasound technology. These measures can only detect clinical tumors. Therefore, there is an urgent need to develop early screening methods with high sensitivity and specificity, such as molecular imaging technology. So far, the most commonly used imaging method for analyzing molecular information is nuclear magnetic resonance. Among these methods, nuclear magnetic resonance has incomparable advantages compared with radioisotopes, but the background noise during imaging is large, the image contrast quality is poor, and the effective observation time of resonance imaging is short. SUMMARY OF THE INVENTION [0003] Based on the technical problems exis...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/14
CPCA61K49/1812A61K49/14
Inventor 曹炳龙
Owner 曹炳龙
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