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Compound nursing agent for treating fibromyalgia syndrome and preparation method of compound nursing agent

A technology of fibromyalgia and nursing agents, applied in the direction of non-central analgesics, medical preparations containing active ingredients, anti-inflammatory agents, etc., which can solve problems such as abnormal paresthesia in hands and feet, affecting the quality of life of patients, and tingling sensation. Achieve good absorption effect, good clinical promotion and application value and prospect, and improve sleep effect

Inactive Publication Date: 2016-09-21
董桂芬
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there will be numbness, tingling, paresthesia in hands and feet, gastrointestinal symptoms and bladder disorders are also common, seriously affecting the quality of life of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1: This embodiment prepares a kind of tablet that is used for the treatment of the compound nursing agent of fibromyalgia syndrome, comprises the composition of following parts by weight: 16 parts of cycloheptene, 12 parts of amitriptyline, paroxetine 10 parts, 8 parts of baclofen, 7.5 parts of propensine, 6 parts of S-adenosylmethionine, 4 parts of glycoside pinexinone, 2 parts of celecoxib, 1 part of lornoxicam, alkaline 0.5 parts of fibroblast growth factor, 0.1 parts of cobaltamide, 18 parts of tryptophan, 24 parts of maltodextrin, and 34 parts of casein phosphopeptide.

[0017] Wherein, the amitriptyline is a derivative of dibenzocycloheptene, which is synthesized by reaction in a microchannel reactor. The microchannel reactor is a multi-step reaction that continuously feeds the product without separation, which not only greatly simplifies the operation steps, saves time and personnel, but also improves the product quality and production cost.

[0018] ...

Embodiment 2

[0025] Embodiment 2: This embodiment prepares a kind of tablet that is used for the treatment of the compound nursing agent of fibromyalgia syndrome, comprises the composition of following parts by weight: 24 parts of cycloheptene, 17.5 parts of amitriptyline, paroxetine 14.5 parts, 11 parts of baclofen, 10.5 parts of propensine, 9 parts of S-adenosylmethionine, 7.5 parts of pinocinone, 5.5 parts of celecoxib, 3 parts of lornoxicam, alkaline 1 part of fibroblast growth factor, 0.4 part of cobaltamide, 20.5 parts of tryptophan, 40 parts of maltodextrin, 45 parts of casein phosphopeptide.

[0026] Wherein, the amitriptyline is a derivative of dibenzocycloheptene, which is synthesized by reaction in a microchannel reactor. The microchannel reactor is a multi-step reaction that continuously feeds the product without separation, which not only greatly simplifies the operation steps, saves time and personnel, but also improves the product quality and production cost.

[0027]Wherei...

Embodiment 3

[0034] Embodiment 3: This embodiment prepares a kind of tablet that is used for the treatment of the compound nursing agent of fibromyalgia syndrome, comprises the composition of following parts by weight: 32 parts of cycloheptene, 23 parts of amitriptyline, paroxetine 19 parts, 14 parts of baclofen, 13.5 parts of propensine, 12 parts of S-adenosylmethionine, 11 parts of pinocinone, 9 parts of celecoxib, 5 parts of lornoxicam, alkaline 1.5 parts of fibroblast growth factor, 0.7 parts of cobaltamide, 23 parts of tryptophan, 56 parts of maltodextrin, and 56 parts of casein phosphopeptide.

[0035] Wherein, the amitriptyline is a derivative of dibenzocycloheptene, which is synthesized by reaction in a microchannel reactor. The microchannel reactor is a multi-step reaction that continuously feeds the product without separation, which not only greatly simplifies the operation steps, saves time and personnel, but also improves the product quality and production cost.

[0036] Where...

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PUM

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Abstract

The invention discloses a compound nursing agent for treating fibromyalgia syndrome and a preparation method of the compound nursing agent. The compound nursing agent consists of the following ingredients: cyclobenzaprine, amitriptyline, paroxetine, baclofen, propantheline, S-adenosylmethionine, nardosinone, celecoxib, lornoxicam, a basic fibroblast growth factor, methycobal, tryptophan, maltodextrin and casein phosphopeptides. The compound nursing agent disclosed by the invention has functions of diminishing inflammation and relieving pain, soothing liver and relieving depression, dispelling wind and eliminating dampness, clearing and activating channels and collaterals, relieving spasms and improving patients' sleep; and based upon clinical verification, the compound nursing agent is relatively high in cure rate on the fibromyalgia syndrome, good in treatment effect, remarkable in curative effect, low in toxic and side effects and free from clinical adverse reactions, and the compound nursing agent has good values and prospects of clinical popularization and application.

Description

technical field [0001] The invention relates to the field of internal medicine nursing medicine, in particular to a compound nursing agent for treating fibromyalgia syndrome and a preparation method thereof. Background technique [0002] Fibromyalgia syndrome (FS) is a non-articular rheumatic disease, clinically manifested as multiple pains and stiffness in the musculoskeletal system, and tenderness points in special parts. Fibromyalgia syndrome can be secondary to trauma, various rheumatic diseases, such as osteoarthritis (osteoarthritis, OA), rheumatoid arthritis (rheumatoid arthritis, RA) and various non-rheumatic diseases (such as hypothyroidism, malignant tumor), etc. This type of fibromyalgia syndrome is called secondary fibromyalgia syndrome (secondary fibromyalgia syndrome), and if it is not accompanied by other diseases, it is called primary fibromyalgia syndrome (primary fibromyagia syndrome). [0003] Its main feature is chronic widespread, symmetrical musculosk...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P29/00A61P21/00A61P19/08A61K38/17A61K31/135A61K31/4525A61K31/195A61K31/352A61K31/7076A61K31/357A61K31/635A61K31/542A61K31/714A61K31/405A61K31/724
CPCA61K9/2059A61K31/135A61K31/195A61K31/352A61K31/357A61K31/405A61K31/4525A61K31/542A61K31/635A61K31/7076A61K31/714A61K31/724A61K38/1709A61K38/1825A61K2300/00
Inventor 董桂芬
Owner 董桂芬
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