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Liposome composition for treating acne, containing conjugate of lysophosphatidylcholine and chlorin e6

A liposome composition, a technology for lysolecithin, which is applied in the field of liposome compositions for treating acne containing a conjugate of lysolecithin and chlorin e6, and can solve unsuccessful use cases, etc. problem, to achieve the effect of treating acne

Active Publication Date: 2016-09-14
H&A PHARMACHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As mentioned above, although application to the treatment of skin diseases such as acne, which is one of the indications of photodynamic therapy, has been proposed, so far, there has been no successful use case in this regard.

Method used

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  • Liposome composition for treating acne, containing conjugate of lysophosphatidylcholine and chlorin e6
  • Liposome composition for treating acne, containing conjugate of lysophosphatidylcholine and chlorin e6
  • Liposome composition for treating acne, containing conjugate of lysophosphatidylcholine and chlorin e6

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0037] Preparation Example: Preparation of LPC-Ce6

[0038] 10 mg of lysophosphatidylcholine (L-α-lysophosphatidylcholine) was dissolved in 10 ml of anhydrous dichloromethane (anhydrous dichloromethane), and 10 mg of chlorin e6 (Ce6), 5.35 mg of N,N '-Dicyclohexylcarbodiimide (N,N'-dicyclohexylcarbodiimide, DCC) and 5.35 mg of 4-dimethylaminopyridine (4-dimethylaminopyridine: DMAP) were added to 10 ml of anhydrous dichloromethane, and stirred 4 hours. Then, the chlorin e6 solution dissolved in anhydrous dichloromethane was mixed with the lysolecithin solution dissolved in anhydrous dichloromethane, and reacted at normal temperature for 48 hours. After the reaction, after evaporation of anhydrous dichloromethane under evapration at 40°C for 30 minutes, the prepared conjugate was refrigerated at 4°C until use.

[0039] [Reaction 2]

[0040]

Embodiment 1

[0041] Embodiment 1: the preparation of the liposome composition containing LPC-Ce6

[0042] At 80°C, dissolve sucrose laurate, polyethylene glycol-5 brassicasterol, sunflower oil and medium chain triglycerides. Then, glycerin, purified water, sodium deoxycholate, and sodium stearyl glutamate were heated to 80° C. or higher, and added to the oil phase, followed by wetting at 100° C. for 1 hour. After cooling the mixture to 40°C, put LPC-Ce6 into it, emulsify it, and pass it through a high-pressure microemulsifier continuously at 1,000 bar 3 times, and then cooled and degassed to obtain a liposome composition.

[0043] Table 1

[0044]

Embodiment 2

[0049] Embodiment 2: Preparation of lotion containing liposomes

[0050] According to the composition in Table 3 below, a lotion containing the liposome of the present invention was prepared.

[0051] table 3

[0052]

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PUM

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Abstract

The present invention relates to a liposome composition for treating acne, comprising 0.001-5 wt% of a conjugate of lysophosphatidylcholine and chlorin e6, 1-10 wt% of sucrose laurate, 0.1-5 wt% of sodium stearyl glutamate, 1-10 wt% of PEG-5 rapeseed sterol, 1-20 wt% of a heavy chain triglyceride, 1-10 wt% of a vegetable oil, 0.1-5 wt% of sodium deoxycholate, 3-10 wt% of glycerin, and the balance of water. The liposome composition of the present invention is very effective for the treatment of acne.

Description

technical field [0001] The invention relates to a conjugate containing lysolecithin and chlorin e6 (chlorin e6) A liposome composition for treating acne, in more detail, relates to a liposome composition for treating acne and a skin care composition comprising it, the liposome composition for treating acne A conjugate comprising 0.001 to 5% by weight of lysophosphatidylcholine (LPC) and chlorin e6, 1 to 10% by weight of sucrose laurate, 0.1 to 5% by weight of stearyl Sodium glutamate (sodium stearoylglutamate), 1 to 10% by weight of polyethylene glycol-5 rapeseed sterol (polyethylene glycol-5rapeseedsterol), 1 to 20% by weight of medium-chain triglyceride (medium-chain triglyceride, MCT ), 1 to 10% by weight of vegetable oil, 0.1 to 5% by weight of sodium deoxycholate (sodium deoxycholate), 3 to 10% by weight of glycerin and the rest of water. Background technique [0002] Photodynamic therapy (PDT), also known as photochemotherapy, is a technology that uses photo-sensiti...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K47/48A61K31/409A61P17/00
CPCA61K9/0014A61K47/183A61K9/1271A61K47/544A61K47/6911A61K41/0071A61K47/10A61K47/14A61K47/26A61K47/44A61P17/00A61K47/50A61K9/127A61K31/409
Inventor 池洪根柳孝暻禹玲珑金贞东曹世熙罗建朴炯
Owner H&A PHARMACHEM
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