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A water-soluble biocompatible fluorescent magnetic nanocluster and its preparation method

A biocompatible, magnetic nanotechnology, applied in the direction of magnetic objects, magnetic materials, inorganic materials, etc., can solve the problems of low packaging efficiency and poor dispersion of packaging methods, achieve adjustable size, improve dispersion, biological good compatibility

Active Publication Date: 2019-07-12
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the packaging efficiency of the encapsulation method is not high, and the surface modification method destroys the hydrophilic groups (such as carboxyl groups) on the surface of the particles, resulting in poor dispersion in the aqueous phase, and the magnetic particles have a strong quenching effect on the surface fluorophores.

Method used

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  • A water-soluble biocompatible fluorescent magnetic nanocluster and its preparation method
  • A water-soluble biocompatible fluorescent magnetic nanocluster and its preparation method
  • A water-soluble biocompatible fluorescent magnetic nanocluster and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Mix 0.9 g of iron oleate and 2.4 g of double-ended carboxyl polyethylene glycol (M n = 600Da) was dissolved in 5 grams of phenyl ether, and after the dissolution was complete, the temperature was raised to 100 ° C for 30 minutes, then heated to reflux for 5 hours, and the reaction solution was cooled to room temperature, and 15 ml of ether and acetone mixed solvent (ether and acetone volume ratio of 5 : 1) Fe with carboxyl groups on the surface is precipitated 3 O 4 magnetic nanoclusters and washed 3 times, the obtained water-soluble biocompatible Fe 3 O 4 Magnetic nanoclusters were dissolved in deionized water and dialyzed for 2 days to obtain purified water-soluble biocompatible Fe 3 O 4 Magnetic nanoclusters, water-soluble biocompatible Fe can be obtained after freeze-drying 3 O 4 Magnetic nanocluster dry powder.

[0034] The obtained magnetic nanocluster dry powder was redissolved in deionized water, and the solution was dropped onto a TEM grid coated with a ...

Embodiment 2

[0036] Mix 0.9 g of iron oleate and 1.8 g of double-ended carboxyl polyethylene glycol (M n =600Da) was dissolved in 5 grams of phenyl ether, and after the dissolution was complete, the temperature was raised to 100 ° C for 30 minutes, then heated to reflux for 2 hours, and after the reaction solution was cooled to room temperature, 15 ml of ether and acetone mixed solvent (ether and acetone volume ratio of 1 :5) Fe with carboxyl groups on the surface is precipitated 3 O 4 magnetic nanoclusters and washed 3 times, the obtained water-soluble biocompatible Fe 3 O 4 The magnetic nanoclusters were dissolved in deionized water, and the filtration was repeated 3 times using a centrifugal filter (with a molecular weight of 1,0000 Da) to obtain purified water-soluble biocompatible Fe. 3 O 4 Magnetic nanoclusters, water-soluble biocompatible Fe can be obtained after freeze-drying 3 O 4 Magnetic nanocluster dry powder.

[0037] The resulting water-soluble biocompatible Fe 3 O 4...

Embodiment 3

[0039] 0.62 g of manganese oleate and 1.8 g of double-ended carboxyl polyethylene glycol (M n =600Da) was dissolved in 5 grams of phenyl ether, and after the dissolution was complete, it was warmed to 100 ° C and kept for 30 minutes, then refluxed for 2 hours, and the reaction solution was cooled to room temperature, and 15 milliliters of diethyl ether and acetone mixed solvent (diethyl ether and acetone volume ratio 1:1: 5) Precipitation of MnO with carboxyl groups on the surface 2 The magnetic nanoclusters were washed 3 times, the obtained water-soluble biocompatible magnetic nanoclusters were dissolved in deionized water, and filtered 3 times using a centrifugal filter (retaining molecular weight of 1,0000 Da) to obtain purified Water Soluble Biocompatible MnO 2 The magnetic nano-cluster can be obtained after freeze-drying to obtain a water-soluble biocompatible magnetic nano-cluster dry powder.

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Abstract

The invention discloses water soluble biocompatible fluorescent magnetic nanoclusters and a preparation method thereof. A metal precursor and biocompatible macromolecules are dissolved in a high-boiling-point non-polar or weakly polar solvent, while magnetic nanoclusters are formed through a high temperature decomposition method, the surface of the nanoclusters are modified with the biocompatible macromolecules in situ, and the water soluble biocompatible magnetic nanoclusters with different sizes are prepared; carboxyl and other functional groups carried on the surface of the nanoclusters are coupled with fluorescent molecules, and thus the fluorescent magnetic bifunctional nanoclusters are obtained. The preparation method has the advantages of simple process, easy operation, and low cost of raw materials; the obtained water soluble biocompatible magnetic nanoclusters have the advantages of adjustable size, strong magnetic response and good biocompatibility, can be used as materials of portable biosensors or related environment biosensors, and also can be used in magnetic resonance imaging, fluorescence imaging, cell screening and other biomedical fields.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, in particular to a water-soluble biocompatible fluorescent / magnetic nanocluster and a preparation method thereof. Background technique [0002] The physical and chemical properties of magnetic nanomaterials are different from those of conventional materials, and they have shown broad application prospects in biomedicine, such as magnetic resonance imaging, disease diagnosis, and magnetothermal therapy. In particular, highly magnetically responsive magnetic materials can be applied to high-efficiency cell separation, drug delivery, and magnetothermal therapy due to their rapid response to external magnetic fields. However, in order to ensure that the material has superparamagnetism, the particle size is generally less than 30 nanometers. Due to the large specific surface area, its magnetic strength is easily reduced by the influence of the surface state and structure, which severe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/06C09K11/02H01F1/01
CPCC09K11/025C09K11/06C09K2211/1088H01F1/0054
Inventor 录驰冲王浩
Owner BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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