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Breast patch and preparation method thereof

A breast and patch technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve problems such as poor decellularization effect, large collagen fiber damage, and high toxicity of disinfectant

Active Publication Date: 2016-08-31
SUZHOU HENRUI DISHENG MEDICAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] (2) Use benzalkonium bromide solution for disinfection, NaCl or EDTA hypertonic solution and detergent Tween, SDS or Triton for decellularization, and finally ethylene oxide sterilization after washing with phosphate buffer, the disinfectant used in this method The toxicity is high, the decellularization reagent used is difficult to clean, and the damage to collagen fibers is also large;
[0007] (3) Repeated freezing and thawing and ultrasonic methods are used to remove cells, which has poor decellularization effect;

Method used

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  • Breast patch and preparation method thereof
  • Breast patch and preparation method thereof

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preparation example Construction

[0102] The inventor has developed a breast patch and a preparation method thereof for the first time through extensive and in-depth research. The method comprises the steps of: peeling and sorting, degreasing and decellularization, cutting, and irradiation sterilization. The breast patch preparation method proposed by the present invention avoids the use of strong acid and alkali and enzymes, and can retain the natural three-dimensional collagen scaffold fiber structure of the pig dermis matrix, so that the breast patch has good mechanical properties to strengthen or repair defective tissue. The prepared breast patch can completely retain the natural structure of the pig dermal matrix, has good tissue compatibility, and has no hidden danger of virus transmission.

[0103] the term

[0104] As used herein, the terms "biological patch cutting device" and "cutting device" all refer to the same device.

[0105] breast patch

[0106] In one embodiment, a cell-free breast patch i...

Embodiment 1

[0200] Step 1. Peeling and sorting

[0201] Provide a dehaired pigskin with the subcutaneous tissue removed, with figure 1 The thickness measuring system shown measures its thickness, and determines the area of ​​uniform skin thickness according to the measurement data (with 0.5mm as the step, the thickness of the skin is divided into 0.8-1.3mm, 1.3-1.8mm, 1.8-2.3mm , 2.3 ~ 2.8mm, 2.8mm or more can be used), divide the skin slices according to the area, and then use a large dermatome to cut off the epidermis and basement membrane to obtain dermal slices with uniform regional thickness.

[0202] Step 2, first degreasing and then decellularization

[0203] Select the process parameters of the dermis skin sheet prepared in step 1 according to the following table, and complete the processing of each step in the order of the following table, and the processing temperature is 20°C:

[0204]

[0205] Step 3. Cutting

[0206] The degreased and decellularized porcine dermal matri...

Embodiment 2

[0216] Step 1. Peeling and sorting

[0217] Provide a dehaired pigskin with the subcutaneous tissue removed, with figure 1 The thickness measurement system shown measures its thickness, and determines the area of ​​uniform thickness of the skin according to the measurement data (with a step of 1mm, the thickness of the skin is divided into 0.8-1.8mm, 1.8-2.8mm, 2.8mm or more, etc. ), divide the skin slices by region, and then use an electric dermatome to cut off the epidermis and basement membrane to obtain dermis skin slices with uniform regional thickness.

[0218] Step 2: decellularize first and then degrease

[0219] Select the process parameters of the dermis sheet obtained in step 1 according to the following table, and complete the processing of each step in the order of the following table, and the processing temperature is 30°C:

[0220]

[0221] Step 3. Cutting

[0222] The decellularized degreased porcine dermal matrix prepared in step 3, using figure 2 The ...

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Abstract

The invention discloses a breast patch and a preparation method thereof. The preparation method comprises the following steps of: paring and sorting; degreasing and decellularizing; cutting; irradiating and sterilizing. By adopting the preparation method of the breast patch provided by the invention, application of strong acid, strong alkali and enzyme can be avoided, the natural three-dimensional collagen scaffold fiber structure of porcine acellular dermal matrix can be maintained, and the breast patch has excellent mechanical performance to achieve the effect of strengthening or repairing defective tissues. The prepared breast patch has tidy edge and smooth curve, can meet basic requirement for medical appliance products, and guarantees biological safety.

Description

technical field [0001] The invention relates to the technical field of tissue engineering medical biomaterials, in particular to a breast patch and a preparation method thereof. Background technique [0002] Breast cancer is one of the most common malignant tumors in women. Because during the treatment of breast cancer, usually in order to completely remove the cancerous tissue and prevent recurrence, the mammary gland and the normal tissue of the breast are all greatly damaged. Mastectomy can cause enormous physical and psychological damage to the patient. In the process of breast reconstruction, most of the breast tissue is usually removed, resulting in weak breast soft tissue. After breast reconstruction is filled with breast prosthesis, it often leads to prosthesis displacement, shedding, and complications such as cyst contracture. [0003] In response to this problem, previous surgeries used autologous fascia flaps or muscle flaps to augment breast soft tissue, and th...

Claims

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Application Information

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IPC IPC(8): A61L27/36
CPCA61L27/362A61L27/3683A61L27/3687A61L27/3691A61L27/3695A61L2430/34A61L2430/40
Inventor 刘博文周宁辉王志东朱鑫建俞鸿飞
Owner SUZHOU HENRUI DISHENG MEDICAL CO LTD
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