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Medical adhesive and preparation method thereof

An adhesive and gelatin technology, used in pharmaceutical formulations, applications, medical science and other directions, can solve the problems of gelled albumin dissolution, insufficient biosafety, virus infection, etc., and achieve strong adhesion and excellent biosafety. Effect

Inactive Publication Date: 2016-08-24
WUHAN HUAYI TONGXIN BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of carcinogenic raw material formaldehyde is not sufficient in terms of biosafety.
There is also a mixed liquid adhesive containing plasma proteins and multifunctional aldehydes that can also be used to bind organisms, but there are also problems - it uses plasma proteins from humans (human serum albumin) and has virus infection problems, as well as the presence of coagulation. The problem of elution of high concentration glutaraldehyde from gelatinized albumin

Method used

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  • Medical adhesive and preparation method thereof
  • Medical adhesive and preparation method thereof
  • Medical adhesive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (Optimization of gelation time) Gelatin powder was added to phosphate buffer saline PBS (-) to prepare 10%, 15%, 20%, 25%, and 30% solutions. Glutaraldehyde was added with distilled water to prepare 0.25%, 0.5%, 0.75%, 1%, 2%, and 4% solutions. Gelatin aqueous solution 10mL, glutaraldehyde aqueous solution 2mL, each kept at 45°C for 30 minutes, then mixed the two liquids, put the mixed liquid into a rotor with a diameter of 2 cm, and started to rotate at 80 rpm. With the increase of the viscosity of the solution, the rotor rotated slowly, and then stopped to measure Gelation time, data obtained on average of 4 times, at 45°C, the experimental results of the relationship between glutaraldehyde (GA) solution concentration and gelation time are as follows figure 1 . From figure 1 It can be seen that under certain temperature and pH conditions, the lower the concentration of gelatin solution, the longer the gelation time. The lower the concentration of glutaraldehyde, th...

Embodiment 2

[0039] (Effect of pH on gelation) Gelatin powder was adjusted to 25% solution by adding phosphate buffer saline PBS (-), and pH of gelatin solution was adjusted to pH 4.0, 7.0, 9.0. In addition, distilled water was added to glutaraldehyde to prepare 0.25%, 0.5%, 0.75%, 1%, 2%, and 4% solutions. Add 10 mL of aqueous gelatin solution to 2 mL of glutaraldehyde aqueous solution, heat each at 45°C for 30 minutes, and mix the two liquids. Put the mixed solution into a rotor with a diameter of 2 cm, and adjust the rotor to rotate at 80 rpm. As the viscosity of the solution increases, the rotor rotates slower, and then stops to measure the gelation time. 4 average data are obtained, the relationship between the pH of the gelatin aqueous solution and the gelation time is as follows figure 2 Show (GA is glutaraldehyde). From figure 2 It can be seen that at a certain temperature and gelatin concentration, high pH environmental conditions promote gelation (gelation time shortens).

Embodiment 3

[0041] (Amount of glutaraldehyde extracted from the gel) Add phosphate buffered saline (PBS) (-) to gelatin powder to prepare 5.0 mL each of 20% and 30% solutions. In addition, add glutaraldehyde to distilled water to prepare 1 mL of 1.0% solution, 45°C After incubation, the two liquids are mixed to make a gel. Compared with commercially available albumin glue (Cryolife International Corp), according to its composition and use, distilled water was added to make 45% albumin solution, and 10% glutaraldehyde aqueous solution was prepared and mixed to make albumin glue. Soak in 5 times the weight of phosphate buffer at 37°C for 1 minute, then measure the amount of glutaraldehyde extracted from the phosphate buffer (hydroxylamine hydrochloride acid-base titration method), obtain the data on average for 4 times, and the results are as follows image 3 , the amount of glutaraldehyde obtained by the dissolution of this gel is much less than that extracted from the albumin gel (GA is g...

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Abstract

The invention provides a medical adhesive. The medical adhesive is mainly composed of glutaraldehyde and gelatin. Under the condition of 30-70°C and the mass ratio of glutaraldehyde aqueous solution to gelatin aqueous solution is 0.01-2, it reacts for 5-100 seconds to form gel Glue, the gel is used as a medical adhesive for bonding biological tissues during the generation process. After the gel is generated, it will no longer adhere to other biological tissues. The adhesive strength of the gel is 20gf / cm 2 Above, the gel tensile strength is 20gf / cm 2 Above, the water content of the gel is 80% to 95%. The mass concentration of the gelatin aqueous solution is 5%-40%, and the mass concentration of the glutaraldehyde aqueous solution is 0.01%-10%. The adhesive of the present invention is immersed in a phosphate buffer solution with a weight ratio of 5 times, soaked at 37° C. for 1 minute, and the extracted glutaraldehyde concentration is 0-50 μg / mL. The medical adhesive has excellent biological safety and strong adhesion, and is suitable for surgical operations as a surgical adhesive to adhere biological tissues, and can also be used as a hemostatic material, an air leakage prevention material, a tissue repair material, a regenerative medical support, etc.

Description

technical field [0001] The invention provides a medical adhesive, specifically a medical surgical adhesive mainly made of glutaraldehyde aqueous solution and gelatin aqueous solution. Background technique [0002] Medical glue is widely used in surgical operations to stop bleeding at the affected part of the biological wound, or to join the biological tissue or internal organs. This medical adhesive is used to bond the biological tissue. After the adhesive is coated on the surface, it is covered with the target tissue After the surface, no other tissue will be adhered, and the adhesive will no longer intervene in the combination of objects. In general, during the period from injury to repair of the tissue surface, protective materials, closure materials, hemostatic materials, and healing prevention materials are covered. Medical adhesives need strong gluing ability to quickly bond biological tissues and biological replacement tissues, and at the same time, they must not irr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/00A61L24/08A61L27/24A61L27/52A61L27/54A61L27/20A61L31/04A61L31/14A61L31/16C08J3/075
CPCA61L24/104A61L24/0015A61L24/0031A61L24/08A61L27/20A61L27/24A61L27/52A61L27/54A61L31/042A61L31/045A61L31/145A61L31/16A61L2300/252A61L2300/412A61L2300/424A61L2400/04C08J3/075C08J2389/00
Inventor 何小明
Owner WUHAN HUAYI TONGXIN BIOLOGICAL TECH CO LTD
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