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Medicinal composition of atenolol and application of medicinal composition in biological medicine

A composition and drug technology, applied in the field of biomedicine, can solve the problems that have not yet been reported on the correlation between atenolol and its pharmaceutical composition and pulmonary fibrosis, and achieve the effect of improving the effect

Inactive Publication Date: 2016-08-10
徐月苗
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there has been no report on the correlation between atenolol and its pharmaceutical composition and pulmonary fibrosis

Method used

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  • Medicinal composition of atenolol and application of medicinal composition in biological medicine
  • Medicinal composition of atenolol and application of medicinal composition in biological medicine
  • Medicinal composition of atenolol and application of medicinal composition in biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0022] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0023] Separation method: (a) Pulverize Nansha ginseng (2kg), extract with 65% ethanol under hot reflux (20L×3 times), combine the extracts, concentrate until there is no alcohol smell (4L), and successively use petroleum ether (4L×3 times) ), ethyl acetate (4L × 3 times) and water-saturated n-butanol (4L × 3 times) extraction, respectively obtain petroleum ether extract, ethyl acetate extract and n-butanol extract; (b) step (a ) in n-butanol extract with AB-8 type macroporous resin for impurity removal, first elute 12 column volumes with 10% ethanol, then elute 15 column volumes with 70% ethanol, collect 70% eluate, d...

Embodiment 2

[0026] Embodiment 2: pharmacological action

[0027] 1. Materials and methods

[0028] 1.1 Animals

[0029]SPF-grade healthy Wistar rats, 60 male and female, weighing (200±20) g, were purchased from the SPF-grade laboratory of Gansu College of Traditional Chinese Medicine and raised in the laboratory.

[0030] 1.2 Reagents and samples

[0031] Atenolol was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Bleomycin hydrochloride (BLM) was purchased from Zhejiang Hisun Pharmaceutical Co., Ltd., and MDA, SOD, and NO test kits were purchased from Nanjing Jiancheng Bioengineering Institute.

[0032] 1.3 Instruments

[0033] A high-speed low-temperature centrifuge (5810R, Eppendorf, USA), a fluorescence microscope (X71, OLYPUS, Japan), and a high-performance liquid chromatography coulomb electrochemical analysis system (HPLC-ECD Coulchem, ESA, USA).

...

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Abstract

The invention discloses a medicinal composition of atenolol and application of the medicinal composition in a biological medicine. The medicinal composition of the atenolol contains the atenolol and a natural product compound (I) which is separated from adenophora tetraphylla and is novel in structure; when independently used, the atenolol and the compound (I) can inhibit pulmonary fibrosis; when the atenolol and the compound (I) are used together, the effect of inhibiting pulmonary fibrosis can be further improved, so that a medicine for inhibiting pulmonary fibrosis can be developed, and compared with the prior art, the medicinal composition has outstanding practical characteristics and remarkable improvement.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of atenolol, in particular to a pharmaceutical composition of atenolol and its application in biomedicine. Background technique [0002] Atenolol is a selective β1 adrenergic receptor blocker suitable for moderate to mild hypertension caused by various reasons, including senile hypertension and hypertension during pregnancy. It is a cardioselective β-receptor blocker with no membrane stabilizing effect and no endogenous sympathomimetic activity. Generally used for sinus tachycardia and premature beats, etc., can also be used for hypertension, angina pectoris and glaucoma. Oral absorption is about 50%, and small doses can pass through the blood-brain barrier. Protein binding rate 6-10%. The peak effect reaches 2 to 4 hours after taking it, and the effect lasts for a long time. The half-life is 6 to 7 hours, and it is mainly excreted in the urine in the original form. ...

Claims

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Application Information

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IPC IPC(8): C07D493/18A61K31/35A61K31/165A61P11/00
CPCA61K31/165A61K31/35A61K36/342C07D493/18A61K2300/00
Inventor 徐月苗
Owner 徐月苗
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