Delayed ion extraction module applicable to time-of-flight mass spectrometer

Abstract

The invention discloses a delayed ion extraction module applicable to a time-of-flight mass spectrometer. The delayed ion extraction module comprises a signal capturing circuit for receiving a synchronous signal of a laser device; an output end of the signal capturing circuit is connected with a signal input end of a signal widening circuit; the output end of the signal widening circuit is connected with the signal input end of a signal delaying circuit; and the output end of the signal delaying circuit is composed of a first triggering signal output end and a second triggering signal output end. The delayed ion extraction module has the advantages that the circuit design is ingenious; when the synchronous signal of the laser device is accurately captured in real time, the synchronous signal with the pulse width of 5ns is widened into standard square wave pulse of 7us; and the intrinsic delay of a circuit is only 38ns, and can be adjusted in a delaying time range of 50-1200ns, so that the requirements on triggering signals of a high-speed acquisition card and a high-voltage pulse module are met. The ion transmission capability is improved to the greatest extent, and the sensitivity and the resolution ratio of a mass spectrum system are effectively improved; and the manufacturing cost can be reduced very well.

Description

technical field [0001] The invention relates to a time-of-flight mass spectrometer, in particular to an ion delay extraction module suitable for the time-of-flight mass spectrometer. Background technique [0002] MALDI-TOFMS (matrix-assisted laser desorption ionization time-of-flight mass spectrometer) mass spectrometry system is a new type of soft ionization biological mass spectrometer. The instrument is mainly composed of two parts: matrix-assisted laser desorption ionization ion source (MALDI) and time-of-flight mass analyzer ( TOF). The principle of MALDI is to irradiate the co-crystallized film formed by the sample and the matrix with laser light. The matrix absorbs energy from the laser and transmits it to the biomolecules; Determination of macromolecules. The principle of TOF is that ions are accelerated to fly through the flight tube under the action of an electric field, and are detected according to the flight time of the detector, that is, the mass-to-charge ra...

AI Technical Summary

Problems solved by technology

Therefore, in order to achieve a stability error within ±200 ps, ​​theoretically, the crystal oscillator frequency must be above 2.5 GHz. Considering the error of the crystal oscillator itself, the crystal oscillator frequency is required to be higher, and it is difficult for general processors to achieve this frequency.

It cannot meet the actual demand of stability ±200ps, which seriously affects the ion transmission and the sensitivity of the mass spectrometer

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