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Medicine composition with clenbuterol hydrochloride and medical application of medicine composition

A technology of clenbuterol hydrochloride and its composition, which is applied in the field of pharmaceutical compositions of clenbuterol hydrochloride, can solve problems such as the correlation between clenbuterol hydrochloride and its pharmaceutical composition and sedation and tranquilization. Strong sedative effect

Inactive Publication Date: 2016-07-20
吴国春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between clenbuterol hydrochloride and its pharmaceutical composition and sedation and tranquilization

Method used

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  • Medicine composition with clenbuterol hydrochloride and medical application of medicine composition
  • Medicine composition with clenbuterol hydrochloride and medical application of medicine composition
  • Medicine composition with clenbuterol hydrochloride and medical application of medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0022] Separation method: (a) Pulverize Bupleurum (2kg), extract with 80% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times) ), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a ) in n-butanol extract with D101 type macroporous resin for impurity removal, first elute 8 column volumes with 10% ethanol, then elute 10 column volumes with 70% ethanol, collect 70% eluate, concentrate under re...

Embodiment 2

[0025] Embodiment 2: pharmacological action

[0026] 1. Materials and methods

[0027] 1.1 Animals

[0028] Kunming mice, weighing 18-25 g, were bred and provided by the Laboratory Animal Laboratory of China Pharmaceutical University.

[0029] 1.2 Reagents and samples

[0030] Clenbuterol hydrochloride was purchased from China Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1.

[0031] 1.3 Mouse grouping and model preparation

[0032] The mice were randomly divided into 4 groups, 12 in each group, respectively the model control group, the clenbuterol hydrochloride group (40 mg·kg -1 ), compound (I) group (40mg·kg -1 ), clenbuterol hydrochloride and compound (I) composition group [20mg·kg -1 Clenbuterol hydrochloride+20mg·kg -1 Compound (I)], orally administered by gavage.

[0033] 1.4 Pentobarbital Sodium Subthreshold Hypnotic Dose Determination

[0034] 1 hour after intrag...

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PUM

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Abstract

The invention discloses a medicine composition with clenbuterol hydrochloride and medical application of the medicine composition. The medicine composition with clenbuterol hydrochloride contains clenbuterol hydrochloride and a natural product compound (I) which has a novel structure; when clenbuterol hydrochloride and the compound (I) work independently, the effects of tranquilizing and allaying excitement can be achieved; when clenbuterol hydrochloride and the compound (I) are combined, the effects of tranquilizing and allaying excitement are more obvious, and the medicine composition can be prepared into a medicine for tranquilizing and allaying excitement; compared with the prior art, the medicine composition disclosed by the invention has outstanding substantive features and a remarkable progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of clenbuterol hydrochloride, in particular to a pharmaceutical composition of clenbuterol hydrochloride and its medical application. Background technique [0002] Clenbuterol hydrochloride is a potent selective β2 receptor agonist, which can relieve bronchial smooth muscle spasm. Its bronchodilation effect is about 25 times that of orcinalin and 100 times that of albuterol, but it has little effect on the cardiovascular system. . It is characterized by quick onset, long maintenance time, small dose (effective oral dose is 30 μg / time), and mild side effects. Oral absorption is better than albuterol, and its anti-asthma effect is about 170 times stronger than that of terbutaline. It can also enhance bronchial ciliary movement, promote the discharge of sputum, and help improve the anti-asthma effect. It takes 10-20 minutes to take effect after oral administration, reache...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/06A61K31/366A61K31/137A61P25/20
CPCC07D407/06A61K31/137A61K31/366
Inventor 吴国春
Owner 吴国春
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