Composite nano medicament-loading material for treating cancer and preparation method thereof

Abstract

The invention discloses a composite nano medicament-loading material for treating cancer and a preparation method thereof. The composite nano medicament-loading material takes UCNPs as a core; a layer of porous material covers the surface of the core; an anti-cancer medicament is loaded in pores; a layer of alkaline manganese compound is deposited on the surface of the porous material; the surface of the alkaline manganese compound is marked with one or more capture molecules or identification molecules. According to the composite nano medicament-loading material for treating cancer and the preparation method thereof, a common antigen antibody identification technology is utilized, and the characteristic that tumour cells can dissolve the alkaline manganese compound is utilized, and the anti-cancer medicament can be released to play a role only after the alkaline manganese compound is dissolved. The alkaline manganese compound in normal cells is hardly dissolved; the anti-cancer medicament is not released or is released slowly, so that the damage to the normal cells caused by the medicament can be greatly reduced; the side effect is low. In addition, an up-conversion luminescence fluorescence imaging technology and a nuclear magnetic resonance technology are combined, so that a double-function imaging mode of a tumour tissue is realized; the identification accuracy rate of the tumour tissue is improved; a treatment effect is observed accurately at any time.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a composite nano drug-loaded material for treating cancer and a preparation method thereof. Background technique [0002] Cancer is the number one killer threatening human health. Chemotherapy drugs can efficiently control and kill cancer cells in human tissues, and are an important means of cancer treatment. [0003] However, due to poor targeting, existing chemotherapy drugs inevitably cause damage to normal cells, resulting in a serious decline in the patient's body resistance, thereby reducing the patient's survival rate. According to statistics, the 5-year survival rate of early cancer patients after regular treatment is 70% to 95%, while the 5-year survival rate of advanced cancer patients after regular treatment is only 10% to 30%. At the same time, to observe the treatment effect, it is necessary to absorb the imaging agent through the human body and then use the corresponding i...

AI Technical Summary

Problems solved by technology

[0005] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide a composite nano drug-loaded material for treating cancer and its preparation method, aiming to solve the problems of poor targeting, large side effects on normal cells and inability to treat existing drug-loaded materials. Timely tracking of medication effects