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Molecular markers for non-invasive diagnosis of bladder cancer

A non-invasive, molecular marker technology used in the field of molecular markers for tumor diagnosis

Active Publication Date: 2016-07-13
陈卫 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical application of these detection methods can reduce the frequency of cystoscopy in patients with bladder cancer, reduce the pain and medical expenses of patients, but it still cannot completely replace cystoscopy

Method used

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  • Molecular markers for non-invasive diagnosis of bladder cancer
  • Molecular markers for non-invasive diagnosis of bladder cancer
  • Molecular markers for non-invasive diagnosis of bladder cancer

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Experimental program
Comparison scheme
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Embodiment Construction

[0019] Methods and Materials

[0020] Sample and Data Collection

[0021]This study was performed after approval from the local ethics review board. All subjects included in the study signed the informed consent. A total of 345 subjects’ morning urine were collected, and the mean value of urine samples was stored at -20°C within 30 minutes after collection until analysis. In the training group, the urine samples of 85 bladder cancer patients were collected from the First Affiliated Hospital of Sun Yat-sen University from November 25, 2013 to October 28, 2014. The 50 control subjects consisted of 6 patients with kidney stones, 5 patients with benign bladder tumors, 7 patients with benign prostatic hyperplasia, 7 patients with hematuria, 6 patients with urinary tract infection and 19 healthy volunteers. 5 patients with benign bladder tumors underwent transurethral resection of bladder tumors, and 7 patients with benign prostatic hyperplasia underwent transurethral resection o...

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Abstract

The invention discloses molecular markers for non-invasive diagnosis of bladder cancer. Based on previous research basis, the inventor detects the protein expression level of AIB1 and EIF5A2 in urine of bladder cancer patients and non-bladder cancer population, and finds that AIB1 and EIF5A2 can serve as new tumor markers for non-invasive diagnosis of bladder cancer, and through combination of AIB1, EIF5A2 and NMP22, the diagnosis accuracy of bladder cancer can further be improved.

Description

technical field [0001] The present invention relates to molecular markers for tumor diagnosis, in particular to molecular markers for non-invasive diagnosis of bladder cancer. Background technique [0002] Globally, nearly 900,000 people are diagnosed with bladder cancer each year, and approximately 250,000 people die from bladder cancer each year [1]. [0003] In my country, bladder cancer is the most common malignant tumor of the urinary system, and bladder cancer can be divided into non-muscle-invasive bladder cancer (T a / T 1 stage) and muscle invasive bladder cancer (T 2 -T 4 Expect). Patients with early bladder cancer can undergo transurethral resection of bladder tumor (TransurethralResectionofBladderTumorTURBT), while patients with muscle-invasive bladder cancer need to undergo total cystectomy and urinary diversion, which seriously affects the quality of life of patients after surgery, and the 5-year survival rate after surgery Only 23%-46%[2]. Therefore, earl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/574
CPCG01N33/5748G01N33/57484G01N33/68G01N33/6875
Inventor 陈炜罗俊航谢丹周邦奋
Owner 陈卫
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