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Bladder cancer patient urine specific metabolite spectrum, establishing method and application

A bladder cancer, specific technology, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as invasiveness, achieve high specificity, good application prospects, and suitable for large-scale screening.

Active Publication Date: 2012-01-18
BGI GENOMICS CO LTD
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the shortcomings of existing bladder cancer diagnosis methods such as traumaticity and invasiveness, the problem to be solved by the present invention is to provide a metabolomics technology to provide a basis for the early diagnosis of bladder cancer. The method has high sensitivity, good specificity, and non-invasive Etc

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  • Bladder cancer patient urine specific metabolite spectrum, establishing method and application
  • Bladder cancer patient urine specific metabolite spectrum, establishing method and application
  • Bladder cancer patient urine specific metabolite spectrum, establishing method and application

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Embodiment Construction

[0017] The embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention and should not be regarded as limiting the scope of the present invention.

[0018] One aspect of the present invention provides a method for establishing a subject's urine metabolite profile, including the following steps:

[0019] (1) Sample collection and processing: the urine samples of the subjects are collected and processed to remove protein and other macromolecules;

[0020] (2) Liquid chromatography mass spectrometry analysis and determination: The metabolite spectrum in urine is obtained by the method based on liquid chromatography and mass spectrometry, and the metabolic spectrum is analyzed.

[0021] Another aspect of the present invention provides a method for establishing a urine-specific metabolite profile of patients with bladder cancer, w...

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Abstract

The invention provides a bladder cancer patient urine specific metabolite spectrum, an establishing method and an application, and especially provides a method for establishing a spectrum of specific metabolites in urine of bladder cancer patients, and a method for screening a related specific biomarker. Through metabonomics, especially metabonomics based on liquid chromatography-mass spectrometry combined technology, the invention establishes a bladder cancer patient urine specific metabolite spectrum. The invention provides a basis for early diagnosis of bladder cancer and bladder cancer diseases with different pathological stages, and also provides a spectrum of specific metabolites in urine of bladder cancer patients and a related specific biomarker. The method provided by the invention has the characteristics of noninvasiveness, convenience, and rapidness, can accurately reflect the difference of metabolite spectra of bladder cancer patients and normal people, and has high specificity.

Description

Technical field [0001] The present invention relates to cancer, particularly bladder cancer. The present invention also relates to metabolomics, especially metabolomics based on liquid chromatography mass spectrometry analysis technology. The invention provides a basis for early diagnosis of bladder cancer and bladder cancer diseases of different pathological stages, and provides a spectrum of specific metabolites in the urine of patients with bladder cancer and related specific biomarkers. In addition, the present invention also provides a method for establishing a specific metabolite profile in the urine of patients with bladder cancer and screening related specific biomarkers. Background technique [0002] Bladder cancer is one of the common clinical tumors, and the incidence of bladder cancer ranks ninth among malignant tumors worldwide [1]. Bladder cancer can occur at any age, even children, but the main age of onset is after middle age, and its incidence increases with ag...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
Inventor 成军栾合密黄颖瑜
Owner BGI GENOMICS CO LTD
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