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Method for measuring contents of various ingredients in cold cough syrup

A cold and cough syrup and content technology, applied in the field of chemical detection, can solve the problem of no method for simultaneously detecting the content of multiple components, and achieve rapid, effective, high-throughput analysis and quality control effects

Inactive Publication Date: 2016-07-13
WUZHOU INST FOR FOOD & DRUG CONTROL
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Problems solved by technology

The original standard only evaluates its quality by traits and inspection items, but there is no method for simultaneously detecting the content of multiple components

Method used

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  • Method for measuring contents of various ingredients in cold cough syrup

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Embodiment 1

[0016] A method for determining the contents of baicalin, puerarin, kaempferol, chlorogenic acid and artemisinin in Ganmao cough syrup, the method comprises the following steps in sequence:

[0017] 1) Preparation of standard solution

[0018] Accurately weigh 5 kinds of standard substances respectively, add 50% methanol aqueous solution to make the concentration 0.1mg / mL, and detect the single standard chromatogram and mixed standard chromatogram of 5 kinds of chemical drugs;

[0019] 2) Prepare the test solution

[0020] Measure 1ml of this product, put it in a 20ml volumetric flask, dissolve it in 50% methanol, treat it ultrasonically for 5 minutes, dilute to the 20ml mark with 50%, mix well, and precisely measure 1mL of the above solution through C18-SPE at a flow rate of about 1mL / min column, eluted with 2mL of 50% methanol, combined the effluent and eluent, filtered through a 0.22μm organic filter membrane to obtain the sample to be tested, and tested by high performanc...

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Abstract

The invention provides a method for measuring the contents of baicalin, baicalein and wogonin in cold cough syrup.The method for measuring the contents of baicalin, baicalein and wogonin in cold cough syrup aims at being accurate in measurement and easy to implement.The method comprises the steps that firstly, a standard solution is prepared; secondly, a test solution is prepared, wherein l ml of the test solution is measured and put in a 20 ml volumetric flask and dissolved with 50% methyl alcohol, ultrasonic treatment is carried out for 5 min, 50% of the solution is used for reaching the constant volume of the 20 ml scale mark, even mixing is carried out, 1 mL of the solution is precisely measured and passes through a C18-SPE column at the flow speed around 1 mL / min, elution is carried out with 2 mL of 50% methyl alcohol, the flowing-out solution and the elution solution are mixed and filtered with a 0.22-micrometer organic membrane, and a sample to be detected is obtained and put into a high performance liquid chromatograph for detection.The method belongs to the technical field of chemical detection.

Description

technical field [0001] The invention provides a method for determining the content of multiple components in cold and cough syrup, specifically, a method for simultaneously detecting five components in cold and cough syrup by using high performance liquid chromatography; it belongs to the technical field of chemical detection. Background technique [0002] Cold and cough syrup is processed from 9 medicinal materials such as skullcap, honeysuckle, kudzu root, and Bupleurum. It is recorded in the third volume of traditional Chinese medicine preparations in the "Drug Standards of the Ministry of Health". For cold or flu, headache, nasal congestion, limb pain and other diseases. Scutellaria baicalensis has the effects of clearing away heat and dampness, purging fire and detoxifying, etc. It is used for cough due to lung heat, high fever and troublesome cough. The original standard only evaluates its quality by traits and inspection items, but there is no method for simultaneous...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/74G01N30/86G01N30/06
CPCG01N30/74G01N30/06G01N30/8634
Inventor 陈学松林冬杰李亚梁慧敏李澄
Owner WUZHOU INST FOR FOOD & DRUG CONTROL
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