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Medicinal composition of gemfibrozil and medicinal application of medicinal composition

A composition and drug technology, applied in the field of biomedicine, can solve the problems that have not yet been reported related to gemfibrozil, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-07-13
宋晓梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between gemfibrozil and its pharmaceutical composition and acute gastric ulcer injury

Method used

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  • Medicinal composition of gemfibrozil and medicinal application of medicinal composition
  • Medicinal composition of gemfibrozil and medicinal application of medicinal composition
  • Medicinal composition of gemfibrozil and medicinal application of medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0021] Sources of reagents: ethanol, petroleum ether, ethyl acetate, n-butanol, and dichloromethane were of analytical grade, purchased from Shanghai Lingfeng Chemical Reagent Co., Ltd. Methanol, of analytical grade, were purchased from Jiangsu Hanbang Chemical Reagent Co., Ltd.

[0022] Separation method: (a) crush Scutellaria baicalensis (2kg), extract with 85% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and successively use petroleum ether (3L×3 times) , ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain sherwood oil extract, ethyl acetate extract and n-butanol extract respectively; (b) step (a) Use D101 macroporous resin to remove impurities from the ethyl acetate extract, first elute with 30% ethanol for 6 column volumes, then use 85% ethanol for 12 column volumes, collect 85% of the ...

Embodiment 2

[0026] Embodiment 2: pharmacological action

[0027] In this example, ethanol was used to prepare the acute gastric mucosal injury model in mice, and the gastric mucosal injury index was measured, including SOD activity, MAD and PEG in mouse gastric tissue. 2 To observe the therapeutic effect of the drug on acute gastric mucosal injury.

[0028] 1. Materials and methods

[0029] 1.1 Animals

[0030] Kunming mice, (25±4) g, half male and half male, were provided by the Animal Center of Shandong University of Traditional Chinese Medicine.

[0031] 1.2 Reagents and samples

[0032] Gemfibrozil was purchased from China National Institute for the Control of Pharmaceutical and Biological Products. Compound (I) is self-made, and the preparation method is shown in Example 1. Sanjiu Weitai Granules were purchased from Sanjiu Pharmaceutical Co., Ltd. Superoxide dismutase (SOD) kits and malondialdehyde (MAD) kits were purchased from Shanghai Lanji Biotechnology Co., Ltd.

[0033] 1....

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PUM

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Abstract

The invention discloses a medicinal composition of gemfibrozil and medicinal application of the medicinal composition. The medicinal composition of gemfibrozil, which is disclosed by the invention, comprises gemfibrozil and a natural product component (I) of a novel structure. When being used independently, gemfibrozil and the compound (I) have protection functions on acute gastric ulcer damage; when being used cooperatively, the protection functions of gemfibrozil and the compound (I) on acute gastric ulcer damage are further enhanced, so that a medicine for treating acute gastric ulcer damage can be developed, and compared with the prior art, the medicinal composition has outstanding substantial characteristics and remarkable improvement.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of gemfibrozil, in particular to a pharmaceutical composition of gemfibrozil and its application in acute gastric ulcer injury. Background technique [0002] Gemfibrozil is a blood-lipid-regulating drug derived from clofibrate. Its mechanism of blood-lipid-lowering action has not yet been fully understood. It may involve peripheral lipolysis, reduce the uptake of free fatty acids by the liver, reduce the formation of intrahepatic triglycerides, and inhibit the formation of very low-density lipoproteins. The synthesis of lipoprotein apoprotein reduces the formation of very low density lipoprotein. Gemfibrozil reduces blood triglycerides and increases blood high-density lipoprotein concentration. Although it can slightly reduce blood low-density lipoprotein cholesterol blood concentration, it may increase low-density lipoprotein in type Ⅳ hyperlipoproteinemia . A 5-year ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/93A61K31/343A61K31/192A61P1/04
CPCC07D307/93A61K31/192A61K31/343A61K2300/00
Inventor 宋晓梅
Owner 宋晓梅
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