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Modular aeration device

A ventilation device, gas technology, applied in mixers with rotating stirring devices, biochemical instruments, transportation and packaging, etc., can solve problems such as troublesome, expensive and ineffective sterilization procedures

Active Publication Date: 2016-06-08
MILLIPORE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Sterilization procedures are expensive, cumbersome, and sometimes ineffective

Method used

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Examples

Experimental program
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example 1

[0059] a series of k L a Tests were run in a 1000L vessel fitted with a 13" circular impeller, baffles, and appropriate transducers to establish a relationship between the area of ​​gas permeable material in a modular sparger and the expected gas transfer efficiency. For these Test, impeller rpm at 60rpm, 10W / m 3 The power input remains constant. exist figure 1 All four positions of the modular sparger use Tyvek ? 1059B as gas permeable material and using air flow rates from 5lpm to 20lpm (from 0.005 to 0.020min -1 air velocity (vvm)), and run three replicates of each condition. A full size sparger was also tested. A simulated medium consisting of water, Pluronic (0.2%), 1XPBS and 50ppm antifoam was used. The results are shown in Figure 7 middle. Data indicate that higher air velocity results in higher k L a value.

[0060] by adding k L a / area / vvm is compared to the area of ​​each modular segment of the sparger to determine gas transfer efficiency. Figure 8 This...

example 2

[0064] Modular spargers according to embodiments disclosed herein allow for the use of more than one type of gas permeable material in the system. Example 1 demonstrates the achievable high-k L a value, where TYVEK ? The material occupies only two of the four modular segments of the sparger mixer. For example, the gas permeable material used for the remaining two modular segments may be chosen to produce ? Materials with larger air bubbles such as Porex ? POR97619 ("PE-10"), POR4920 ("PE-40"), and POR4903 ("PE-90"), all of which are made of polyethylene.

[0065] Using the vessel of Example 1, these three types of gas permeable materials were evaluated in one and two segments of the sparging mixer over a range of air flow rates from 5 lpm to 50 lpm (0.005 vvm to 0.05 vvm), with impeller rpm at held constant at 60 rpm. The results are summarized in the Figure 11 middle.

[0066] In general, larger pore size (PE-90) materials tend to give lower k L a value, however the ...

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Abstract

An aeration device, and containers or vessels incorporating the same are provided. The aeration device can comprise a plurality of interchangeable aeration elements that can produce gas bubble of different sizes and deliver them to the contents of the container. Also disclosed are containers, such as a disposable or single-use container, optionally having one or more inlets and one or more outlets, an aeration device including a plurality of aeration elements, and a mixer to cause mixing, dispersing, homogenizing and / or circulation of one or more ingredients contained or added to the container. The container can be a bioreactors and the aeration device controls the dissolved gas concentration content of the bioreactor contents, thereby facilitating proper growth of cell cultures in the bioreactor.

Description

[0001] This application claims priority to US Provisional Application Serial No. 61 / 897,246, filed October 30, 2013, the disclosure of which is incorporated herein by reference. technical field [0002] Embodiments disclosed herein relate to a modular aeration device usable in a container or vessel, such as a bioreactor, and in particular, such as a single-use stirred tank bioreactor, and to a modular aeration device and Mixing components, and a container or vessel containing them. Background technique [0003] Traditionally, fluids, such as biological materials, are handled in systems utilizing stainless steel containers or vessels. These containers are sterilized after use so that they can be reused. Sterilization procedures are expensive, cumbersome, and sometimes ineffective. [0004] To provide greater flexibility in the manufacturing process and reduce the time required to achieve effective regeneration of equipment, manufacturers have begun to use disposable sterili...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01F3/04B01F27/91B01F33/40
CPCC12M29/06C12M27/02B01F23/23124B01F23/231262B01F23/233B01F23/23351B01F23/23362B01F27/91B01F33/4534B01F35/2132B01F35/2211B01F35/513B01F2101/44C12Q3/00
Inventor A.伍德D.克劳斯A.汉森K.德尔J.麦克斯维尼
Owner MILLIPORE CORP
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