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Oral administration composition of colistin

A technology of colistin and composition, which is applied in the field of compositions for improving the gastrointestinal absorption of colistin, can solve problems such as no reports on the absorption of colistin, achieve good in-vivo synergy, improve absorption, reduce Nephrotoxic and neurotoxic effects

Inactive Publication Date: 2016-06-01
李志海 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] It has been reported in the literature that medium-length carbon chain fatty acids and sodium lauryl sulfate can improve the absorption of some low-absorption drugs, but whether these absorption enhancers can promote the absorption of colistin has not been reported

Method used

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  • Oral administration composition of colistin
  • Oral administration composition of colistin
  • Oral administration composition of colistin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1. powder

[0021] Each component is calculated according to the following parts by weight, and is prepared into a powder according to a conventional method.

[0022]

Embodiment 2

[0023] Embodiment 2. Preparation of powder

[0024] Each component is calculated according to the following parts by weight, and is prepared into a powder according to a conventional method.

[0025] Colistin 1

[0026] Sodium Laurate 1

Embodiment 3

[0027] The preparation of embodiment 3 capsules

[0028] Each component is calculated according to the following parts by weight, and prepared into capsules according to a conventional method.

[0029]

[0030]

[0031] Note: In all the above prescriptions, each raw material is passed through an 80-mesh sieve, mixed evenly, and packed into 20 capsules.

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Abstract

The invention discloses an oral administration composition of colistin and belongs to the technical field of medicines. The oral administration composition of the colistin is prepared from the following components in parts by weight: 1 part of colistin, 0.01 to 10 parts of absorption promoter and 0 to 100 parts of pharmaceutically acceptable auxiliaries and excipient. In addition, antibacterial drugs are added into a formula, and the addition amount of the antibacterial drugs is one third of therapeutically effective amount. According to the composition, the absorbance of the colistin is greatly improved, the possibility of oral administration treatment for systemic bacterial infection by the colistin is realized; the oral administration composition can replace an injection, so the prejudice of the prior art is overcome. Besides, when the composition contains other antibacterial drugs, a good synergic effect in vivo is realized, and when two thirds of dose of the colistin is reduced, an ideal bacterial infection resisting effect can be still maintained, so that the renal toxicity and the neurotoxicity of the colistin are greatly reduced.

Description

technical field [0001] The invention relates to a composition for improving the gastrointestinal absorption of colistin, which belongs to the technical field of medicine. Background technique [0002] Colistin (commonly colistin sulfate) is a cheap antimicrobial drug extracted by microbial fermentation. Due to its unique chemical structure, it is not easy to produce drug resistance to Gram-negative bacteria. It is currently an effective drug for the treatment of drug-resistant bacteria, especially multi-drug-resistant bacterial infections. However, this product has certain nephrotoxicity. And neurotoxicity, long-term use damages human or animal health. At present, when colistin is used to treat systemic infections in humans or animals, it is mostly prepared as injections. Colistin is a kind of alkaline cationic surfactant from the structural point of view, and it is almost not absorbed in the gastrointestinal tract after oral administration (edited by the Chinese Veterinar...

Claims

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Application Information

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IPC IPC(8): A61K38/12A61K47/20A61P31/04A61K31/496A61K31/43
CPCA61K38/12A61K9/145A61K9/4858A61K31/43A61K31/496A61K2300/00
Inventor 李志海李森张卫红
Owner 李志海
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