Pharmaceutical composition for treating cough variant asthma and pharmacologic action thereof

A technology for variant asthma and pharmacology, applied in the field of medicine, can solve the problems of unscientific clinical research design, insufficient evidence strength, and publication bias.

Inactive Publication Date: 2016-05-25
JINAN KANGZHONG PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some deficiencies: ① Most of the clinical research designs of traditional Chinese medicine preparations are unscientific, most of the research methods are randomized open controlled trials, lack of large-scale, multi-center, random blind trials, and insufficient evidence strength
②The selection of the control group for clinical trials lacks a placebo control, and the selection of positive control drugs is unscientific. There are few nationally recognized effective and safe drugs for treating similar diseases as control drugs. It is difficult for clinical trials to scientifically and accurately evaluate the efficacy of experimental drugs. effectiveness
③The curative effect of clinical research is mostly positive results, adverse reaction reports are rare, and there is a serious publication bias
④ There is a lack of reports on the pharmacological research of traditional Chinese medicine in the treatment of this disease

Method used

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  • Pharmaceutical composition for treating cough variant asthma and pharmacologic action thereof
  • Pharmaceutical composition for treating cough variant asthma and pharmacologic action thereof
  • Pharmaceutical composition for treating cough variant asthma and pharmacologic action thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Embodiment 1: the granule preparation of medicine of the present invention

[0065] Take the following raw materials by weight:

[0066] Aconite 900g Roasted Ephedra 600g Licorice 600g

[0067] The above-mentioned crude drug is prepared according to the following method:

[0068] Add water to decoct the aconite, ephedra, and licorice in the weight ratio twice, add 12 times the amount for the first time, decoct for 2 hours, add 10 times the amount for the second time, decoct for 2 hours, combine the medicinal liquid, and decoct for 2 hours. Liquid filtration, take the filtrate, concentrate to a relative density of 1.10-1.15 (60°C), add ethanol to make the alcohol content reach 70%, precipitate, let it stand for 24 hours, absorb the supernatant, recover the ethanol, and obtain the alcohol precipitation liquid concentrating, drying, and pulverizing the alcohol precipitation liquid to obtain dry cream powder; fully mixing the obtained dry cream powder with an appropriate ...

Embodiment 2

[0077] Embodiment 2: the capsule preparation of medicine of the present invention

[0078] Aconite 900g Roasted Ephedra 600g Licorice 600g

[0079] The above-mentioned crude drug is prepared according to the following method:

[0080]Add water to decoct the aconite, ephedra, and licorice in the weight ratio twice, add 12 times the amount for the first time, decoct for 2 hours, add 10 times the amount for the second time, decoct for 2 hours, combine the medicinal liquid, and decoct for 2 hours. Liquid filtration, take the filtrate, concentrate to a relative density of 1.10-1.15 (60°C), add ethanol to make the alcohol content reach 70%, precipitate, let it stand for 24 hours, absorb the supernatant, recover the ethanol, and obtain the alcohol precipitation liquid concentrating, drying, and pulverizing the alcohol precipitation liquid to obtain dry cream powder; fully mixing the obtained dry cream powder with an appropriate amount of dextrin, granulating with ethanol liquid as a...

Embodiment 3

[0089] Embodiment 3: the tablet preparation of medicine of the present invention

[0090] Take the following raw materials by weight:

[0091] Aconite 600g Roasted Ephedra 300g Licorice 300g

[0092] The above-mentioned crude drug is prepared according to the following method:

[0093] Add water to decoct the aconite, ephedra, and licorice in the weight ratio twice, add 10 times the amount of water for the first time, decoct for 1 hour, add 8 times the amount of water for the second time, decoct for 1 hour, combine the medicinal liquid, and decoct for 1 hour. Liquid filtration, take the filtrate, concentrate to a relative density of 1.10-1.15 (60°C), add ethanol to make the alcohol content reach 80%, precipitate, stand for 32 hours, absorb the supernatant, recover ethanol, concentrate, dry, Crush, granulate with ethanol as a binder, dry, and press into tablets.

[0094] Take the above preparation to measure the alkaloid content of Fuzi:

[0095] Chromatographic conditions ...

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating cough variant asthma. The pharmaceutical composition is prepared from, by weight, 6-20 parts of radix aconiti carmichaeli, 3-12 parts of honey-fried herba ephedrae and 3-12 parts of licorice roots. The pharmaceutical composition has the effects of relieving asthma, relaxing tracheal smooth muscles and reducing the leukotriene content of lung tissue. According to long-term observation, when the pharmaceutical composition is used for treating the cough variant asthma, the cough symptom can be rapidly removed, the cure rate is high, both symptoms and root causes are treated, and the cough variant asthma does not relapse after being cured.

Description

technical field [0001] The invention relates to medicines, in particular to a pharmaceutical composition for treating cough variant asthma, which belongs to the technical field of medicines. technical background [0002] Cough variant asthma (CVA), also known as cough-type asthma, occult asthma or allergic cough, is a special type of asthma. It mainly manifests as persistent or chronic cough in bed, without clinical manifestations of infection, or after a long period of antibiotics Treatment was ineffective, and bronchodilators relieved coughing attacks. Due to the special manifestations of CVA, it is often ignored or misdiagnosed as repeated upper respiratory tract infection, chronic bronchitis, etc., which delays the best time for treatment and aggravates the patient's condition. [0003] Cough variant asthma is not asthma. It is a persistent inflammatory response caused by the body to antigenic or non-antigenic stimuli. If it is not actively treated, it can develop into ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61P11/14A61P11/06
CPCA61K9/0095A61K9/08A61K9/1652A61K9/2013A61K36/17A61K36/484A61K36/714A61K2300/00
Inventor 郭美莹刘金磊石红艳赵颖
Owner JINAN KANGZHONG PHARMA TECH DEV
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