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Method for extracting rutin from Japanese pagodatree flower buds and preparing quercetin

A technology of quercetin and Sophora japonica, which is applied to the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of low purity and low extraction rate of active ingredients, and achieve low magazine content and easy Preservation, high-purity effect

Inactive Publication Date: 2016-05-04
张婷婷
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Problems solved by technology

[0006] The object of the present invention is a method for extracting rutin from Sophora japonica and preparing quercetin, which overcomes the problems of low extraction rate and low purity of active ingredients in traditional medicinal Sophora japonica using water decoction, and utilizes rutin High-purity rutin was obtained through a property-designed extraction process, and quercetin was prepared from rutin

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0017] 1. Extraction of rutin

[0018] Take 200g of the crude drug rutin in a container, rinse it with clean water, take out the floating buds and discard the sinking impurities, put the washed buds in the container and add 1000ml of distilled water to heat, ultrasonically extract at 30KHz-50KHz for 45min, and keep replenishing The evaporated water is filtered while it is hot, and the filtrate is collected. The filter residue is then extracted with 400ml of distilled water by the same method as above. The two filtrates are combined and concentrated to 600ml. 0-8° C.), washed three times, drained, dried below 60° C., and weighed to obtain 19.3 g of crude rutin, and the yield of crude rutin could be calculated as 9.65%.

[0019] 2. Refined rutin

[0020] Grind the crude rutin finely, add 95% ethanol to reflux to dissolve (70 ml of ethanol needs to be added for every 2 g of rutin), filter while hot, collect half of the filtrate and concentrate to 30%-40% of the original volume (...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine and particularly relates to a method for extracting rutin from Japanese pagodatree flower buds and preparing quercetin. The quercetin as an effective component in the Japanese pagodatree flower buds belongs to flavonoid compounds, rutin is rutinoside of the quercetin, and the rutin and the quercetin belong to different substances and have different pharmacological characteristics. By the aid of the property that the rutin has different solubility in cold water and hot water, the rutin is separated and extracted from the Japanese pagodatree flower buds and subjected to ethyl alcohol reflux refining, refined rutin with higher purity can be obtained, then the rutin is hydrolyzed in an acidic condition, the quercetin can be obtained and subjected to recrystallization with ethyl alcohol, and yellow acicular crystals can be obtained and are refined quercetin products.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine extraction, and in particular relates to a method for extracting rutin from Sophora japonica and preparing quercetin. Background technique [0002] Sophora japonica is also known as white locust tree, Sophora japonica, Sophora japonica rice, Sophora japonica seed. Sophora japonica rice has the effect of cooling blood and stopping bleeding, clearing liver and purging fire, and Sophora japonica can lower blood pressure, prevent stroke, cool blood and stop bleeding, and anti-inflammation. The active ingredient in Sophora japonica is rutin. Rutin, also known as rutin and purple quercetin, is a flavonoid compound. It mainly exists in the flower buds (Sophora japonica L.) and fruit (Sophora japonica L.) of the leguminous plant, the whole grass of the Rutaceae plant Rutaceae, and the seedlings of the Polygonaceae plant buckwheat. [0003] The rutin (rutin) contained in Sophorae jap...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07H17/07C07H1/08
CPCC07D311/30C07H1/08C07H17/07
Inventor 张婷婷
Owner 张婷婷
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