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A scaffold material for treating femoral head necrosis and its preparation method

A technology of femoral head necrosis and scaffold material, which is applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems of osteoarthritis joint function, femoral head collapse, damage and other problems, and achieves no cytotoxicity and biocompatibility. good effect

Inactive Publication Date: 2018-10-16
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Avascular necrosis of the femoral head, especially non-traumatic avascular necrosis of the femoral head, occurs frequently in young and middle-aged people. Although the causes are different, they have similar pathological processes and results. Femoral head collapse, osteoarthritis, and impaired joint function occur, bringing heavy burdens to the family and society

Method used

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  • A scaffold material for treating femoral head necrosis and its preparation method
  • A scaffold material for treating femoral head necrosis and its preparation method
  • A scaffold material for treating femoral head necrosis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The preparation method of the support material that is used for the treatment of femoral head necrosis:

[0045] ① Preparation of deer antler glue

[0046] Crush the antler slices and put them in a round bottom flask, add 4-5 times (volume) of distilled water, and boil them; take the juice every 3 hours, add water and cook until the antlers are soft, and can be crushed by hand; Combine the gum juices, filter to remove residue, and concentrate under reduced pressure at 50°C with a vacuum concentrator to 1.2g / ml; cool to room temperature to obtain an antler glue solution, sterilize by radiation, and store at 4°C.

[0047] ②Preparation of deproteinized bone

[0048] Take the cancellous bone at the lower end of the porcine femur, soak it in normal saline for 24 hours, clean it with distilled water after taking it out, put it into a sealable container containing 30% (v / v) H 2 o 2 Put the solution in a glass bottle and place it in a constant temperature water bath at 37°C ...

Embodiment 2

[0054]The preparation method of the support material that is used for the treatment of femoral head necrosis:

[0055] ① Preparation of deer antler glue

[0056] Crush the antler slices and put them in a round bottom flask, add 4–5 times (volume) of distilled water, and boil them; take the juice every 3 hours, add water and cook until the antlers are soft and can be crushed by hand; combine Glue juice, filtered to remove slag, concentrated under reduced pressure at 50°C with a vacuum concentrator to 1.0g / ml; cooled to room temperature to obtain antler glue solution, sterilized by radiation, and stored at 4°C.

[0057] ②Preparation of deproteinized bone

[0058] Take the cancellous bone at the lower end of the porcine femur, soak it in normal saline for 24 hours, clean it with distilled water after taking it out, put it into a sealable container containing 30% (v / v) H 2 o 2 Put the solution in a glass bottle and place it in a constant temperature water bath at 37°C for 48 ho...

Embodiment 3

[0064] The preparation method of the support material that is used for the treatment of femoral head necrosis:

[0065] ① Preparation of deer antler glue

[0066] Crush the antler slices and put them in a round bottom flask, add 4–5 times (volume) of distilled water, and boil them; take the juice every 3 hours, add water and cook until the antlers are soft and can be crushed by hand; combine Glue juice, filtered to remove residue, concentrated under reduced pressure at 50°C with a vacuum concentrator to 1.33g / ml; cooled to room temperature to obtain antler glue solution, sterilized by radiation, and stored at 4°C.

[0067] ②Preparation of deproteinized bone

[0068] Take the cancellous bone at the lower end of the porcine femur, soak it in normal saline for 24 hours, clean it with distilled water after taking it out, put it into a sealable container containing 30% (v / v) H 2 o 2 Put the solution in a glass bottle and place it in a constant temperature water bath at 37°C for ...

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Abstract

The invention relates to a material of a support for treating femoral head necrosis and a preparation method thereof. The material is prepared through the steps of mixing deerhorn glue-deproteinized bone powder with polycaprolactone according to the mass ratio of 1 to 4-5 and pouring the obtained mixture into an FDM three-dimensional printing ink box for printing. The deerhorn glue-deproteinized bone powder is prepared through the steps that deproteinized bones are put into a deerhorn glue solution, mixing, crosslinking and freeze-drying are conducted, and then superfine grinding is conducted on the obtained product, wherein the mass ratio of deerhorn glue to the deproteinized bones is 1 to 8.5-10. The support can enhance supporting to prevent femoral heads from collapse, sufficient structural support is provided to joint cartilages, and meanwhile sclerotin healing process is facilitated to accelerate creeping substitution of sclerotin.

Description

technical field [0001] The invention relates to a scaffold material for treating femoral head necrosis, in particular to a cell scaffold material for treating ischemic femoral head necrosis and a preparation method thereof. Background technique [0002] Avascular Necrosis of the Femoral Head (ANFH) is a pathological process caused by the death of bone cells, bone marrow hematopoietic cells and adipocytes of the femoral head due to various reasons. disabling disease. Without treatment, more than 70% of patients will have to undergo prosthetic replacement 3-4 years after diagnosis, and many patients will have to face multiple joint replacements in their lifetime. It is a heavy burden both mentally and financially. Currently used joint replacement surgery and drug therapy have certain limitations. How to preserve the autologous femoral head, prevent it from collapsing, activate the cells in the necrotic area, achieve the "regeneration" of the bone, and fundamentally solve th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/18A61L27/50
CPCA61L27/18A61L27/3608A61L27/365A61L27/50A61L2430/02C08L33/06
Inventor 王平高志惠张丽美孙铁锋师彬张猛李晓沫
Owner SHANDONG ACAD OF CHINESE MEDICINE
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