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Glyceryl monolinoleate coprecipitation method for preparing propolis liquid

A technology of glycerol monolinoleate and propolis liquid, which can be applied in the directions of non-active ingredient medical preparations, active ingredients-containing medical preparations, food science, etc. problem, to achieve the effect of stable liquid state

Active Publication Date: 2016-05-04
杭州蜂之语蜂业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The present invention is in order to solve the deficiencies in the prior art, the present invention provides a kind of production method that adopts glycerol monolinoleate coprecipitation method to prepare propolis liquid, it not only It solves the problem of the dissolution rate of propolis. At the same time, other bioactive components in propolis can be retained to the maximum extent during the production process. The excipients used can be widely used in production without being limited by the use limit of national standards. In addition to the above-mentioned problems that by-products that are harmful to the human body or that the auxiliary materials are harmful to the human body are easily produced after the use of auxiliary materials, the use of co-precipitation method to produce propolis liquid also has a major advantage of greatly reducing the amount of propolis residues. According to practice, the amount of propolis residues is only Less than 0.1% of the amount of propolis thrown, there is almost no residue, and the dissolution is more thorough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The method for preparing propolis liquid, comprises the steps:

[0037] 1) dissolving 1kg of refined propolis in 99kg95% edible alcohol (ethanol) to make a 1% propolis alcohol solution containing propolis by weight;

[0038] 2) Based on the weight ratio of glyceryl monolinoleate and propolis as 1:0.01, put 100kg of 1% propolis liquid into 99kg of glyceryl monolinoleate, or put glyceryl monolinoleate into the propolis liquid , stirring and dissolving, can be slightly heated at 50 ℃ to dissolve, and finally form a transparent eutectic.

[0039] 3) drying this eutectic matter by vacuum drying, the drying temperature is 50°C, and the vacuum degree is -0.090Mpa to obtain propolis liquid, the weight percentage of propolis in the propolis liquid is 1%, and the amount of propolis residue detected is undetected ( Detection limit <0.01%).

[0040] The drying method here can also be replaced by hot air drying method, reduced pressure rotary evaporation, and reduced pressure dryi...

Embodiment 2

[0042] The method for preparing propolis liquid, comprises the steps:

[0043]1) Dissolving 1.2kg of refined propolis in 0.8kg95% edible alcohol (ethanol) to make a propolis alcohol solution containing 60% propolis by weight;

[0044] 2) Based on the weight ratio of glyceryl monolinoleate and propolis as 1:1, put 2kg of 60% propolis liquid into 0.8kg of glyceryl monolinoleate, or put glyceryl monolinoleate into the propolis liquid , Stir to dissolve, and can be dissolved by slight heating at 40°C, and finally form a transparent eutectic.

[0045] 3) Dry the eutectic product by vacuum drying, the drying temperature is 60°C, and the vacuum degree is -0.1Mpa to obtain propolis liquid. The weight percentage of propolis in the propolis liquid is 60%, and the amount of propolis residue detected is 0.02% of the propolis amount. %.

[0046] The drying method here can also be replaced by hot air drying method, reduced pressure rotary evaporation, and reduced pressure drying method. D...

Embodiment 3

[0048] The method for preparing propolis liquid, comprises the steps:

[0049] 1) dissolving 1kg of refined propolis in 3kg95% edible alcohol (ethanol) to make a 25% propolis alcohol solution containing propolis by weight;

[0050] 2) Based on the weight ratio of monolinoleic acid glyceride and propolis as 1:2, put 4kg of 25% propolis alcohol solution into 2kg monolinoleic acid glyceride, or put monolinoleic acid glyceride into propolis In the liquid, stir to dissolve, and can dissolve with slight heat at 60°C, and finally form a transparent eutectic;

[0051] 3) This eutectic product is dried by vacuum drying, the drying temperature is 55° C., and the vacuum degree is -0.095Mpa to obtain propolis liquid. The weight percentage of propolis in the propolis liquid is 33.3%, and the amount of residual propolis is not detected ( Detection limit <0.01%).

[0052] The drying method here can also be replaced by hot air drying method, reduced pressure rotary evaporation, and reduced ...

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PUM

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Abstract

The invention provides a glyceryl monolinoleate coprecipitation method for preparing propolis liquid, which solves the problem of dissolution rate of propolis and other bioactive components in the propolis can be kept to the maximum extent in a production process, used auxiliary materials can be widely applied to the production without limitation of a national standard use limit, the problem that after the auxiliary materials are used, side products unfavorable for a human body are generated or the auxiliary materials are unfavorable for the human body is solved, one big advantage of producing the propolis liquid by using a coprecipitation method is great reduction of residue of the propolis, practice shows that the residue of the propolis is only below 0.1% of the charged propolis, nearly no residue exists, the dissolution is thorough, a technical solution takes glyceryl monolinoleate as the auxiliary material and edible alcohol as a solvent, a precipitation technology is adopted to dissolve propolis in the glyceryl monolinoleate and forms a stable liquid state, and the alcohol is dried and recycled to obtain the propolis liquid.

Description

technical field [0001] The invention belongs to the field of preparation of health care products, and in particular relates to a method for preparing propolis liquid by adopting a co-precipitation method of glycerol monolinoleate. Background technique [0002] Propolis is listed in the Pharmacopoeia of the People's Republic of China. It is a kind of medicine that is difficult to dissolve in water. When producing products, in order to ensure that propolis can be effectively used by the human body, the problem of propolis dissolution must be solved. The active ingredients of propolis in propolis products must be in the Dissolution in water or gastric juice, that is, propolis must have good hydrophilicity. In my country, propolis belongs to the category of health food and drug management, and mainly exists in the form of health food. The dosage forms include propolis tablets, propolis capsules, propolis soft capsules, propolis liquid, etc. There are more than 400 health food ap...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/644A61K47/14A61K47/10A23L21/20
CPCA61K35/644A61K47/10A61K47/14
Inventor 周萍
Owner 杭州蜂之语蜂业股份有限公司
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