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Preparation method of temperature-sensitive type gracilaria agar complex gel

A complex, temperature-sensitive technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, drug delivery, etc., can solve the problems of low effective utilization of drugs, poor gel stability, and low encapsulation efficiency. The effect of strong drug loading capacity, long sustained release time and low cost

Inactive Publication Date: 2016-04-20
CHANGZHOU SIYU ENVIRONMENTAL PROTECTION MATERIAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem mainly solved by the present invention: aiming at the poor stability of the gel prepared by poloxamer at present, the low effective utilization rate of the medicine, and the low encapsulation efficiency, a kind of raw material mainly using fresh Gracilaria is provided, respectively After being mixed with sterile water three times under specific conditions, Gracilaria agar was prepared into Gracilaria agar, and mixed with ethanol and other substances to form Gracilaria agar ethanol solution, and then mixed with chloroacetic acid and other substances under specific conditions, filtered, concentrated, Dried to a gel

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019] Example 1 First select fresh Gracilaria, wash it with water and dry it in the sun, then place it in an oven at 60°C for 3 hours to prepare dried Gracilaria, and then dry it according to the solid-to-liquid mass ratio of 1:10. Gracilaria was stirred and swelled with sterile water, then sealed and fermented at 30°C for 3 days; after the fermentation was completed, it was filtered and the filter residue was collected, washed 5 times with sterile water, and then the solid-liquid mass ratio Stir and mix it with sterile water at a ratio of 1:10, then add a sodium hydroxide solution with a mass concentration of 20% to the above solution at a mass ratio of sterile water and sodium hydroxide solution of 1:1, and stir and mix for 15 minutes. Heating in a constant temperature water bath at 70°C for 3 hours; after the heating in the water bath is completed, collect the filter cake by suction filtration under reduced pressure, and wash it with distilled water for 5 times. 6.5, then ...

example 2

[0021]First, fresh Gracilaria was selected, washed with water and dried in the sun, and then dried in an oven at 55°C for 2 hours to prepare dried Gracilaria, and then the dried Gracilaria was prepared according to the solid-to-liquid mass ratio of 1:10 Stir and swell with sterile water, then seal it and place it at 20°C for 2 days of fermentation treatment; after the fermentation is completed, filter it and collect the filter residue, wash it with sterile water 3 times, and then press the solid-to-liquid mass ratio of 1: 10 Stir and mix it with sterile water, and then add a sodium hydroxide solution with a mass concentration of 20% to the above solution according to the mass ratio of sterile water and sodium hydroxide solution at 1:1, and stir and mix for 10 minutes. Heat in a constant temperature water bath at ℃ for 2 hours; after the heating in the water bath is completed, collect the filter cake by suction filtration under reduced pressure, and wash it with distilled water ...

example 3

[0023] First, fresh Gracilaria was selected, washed with water and dried in the sun, then dried in an oven at 57°C for 2.5 hours to prepare dried Gracilaria, and then the dried Gracilaria was prepared according to the mass ratio of solid to liquid at 1:10 Stir and swell with sterile water, then seal it and place it at 25°C for 3 days of fermentation treatment; after the fermentation is completed, filter it and collect the filter residue, wash it with sterile water 4 times, and then press the solid-liquid mass ratio of 1 :10 it is stirred and mixed with sterile water, then by sterile water and sodium hydroxide solution mass ratio 1:1, the sodium hydroxide solution that the mass concentration is 20% is added in the above-mentioned solution, after stirring and mixing for 12min, in Heat in a constant temperature water bath at 66°C for 2 hours; after the heating in the water bath is completed, collect the filter cake by suction filtration under reduced pressure, and wash it with dis...

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Abstract

The invention relates to a preparation method of temperature-sensitive type gracilaria agar complex gel, and belongs to the technical field of gel preparation. The method includes the steps of preparing gracilaria agar from fresh gracilaria serving as the raw materials together with thrice sterile water under specific conditions, mixing gracilaria agar with ethyl alcohol and other substances to form a gracilaria agar ethanol solution, making the solution mixed with chloroacetic acid and other substances under specific conditions, and conducting filtering, concentrating and drying to obtain the gel. The method has the advantages that the medicine carrying capacity is strong, the slow-release time is long, and high stability is achieved; the medicine utilization rate is high and is improved by 10-15%, the preparation steps are simple, and cost is low.

Description

technical field [0001] The invention relates to a preparation method of temperature-sensitive Gracilaria agar complex gel, belonging to the technical field of gel preparation. Background technique [0002] Polymers for thermosensitive gels have the property of undergoing a phase transition from solution to gel in response to changes in storage conditions and temperature at the site of administration. Temperature-sensitive drug-containing gel has the advantages of good fluidity, convenient use, long residence time, high bioavailability, and good controlled release performance. It is widely used in pharmacy and can be made into embedded drug controlled release The system is injected into the body to avoid the pain caused by the implantation operation. In addition, the temperature-sensitive gel can also carry biomacromolecular drugs and maintain the activity of biomacromolecules. Therefore, the temperature-sensitive gel drug-loading system has been Become a bright spot in phar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/06
CPCA61K47/36A61K9/0019A61K9/0048A61K9/06
Inventor 孙春辉薛红娟高力群
Owner CHANGZHOU SIYU ENVIRONMENTAL PROTECTION MATERIAL SCI & TECH
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