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Application of icariin in the preparation of drugs for preventing or treating pulmonary fibrosis

A technology of icariin and pulmonary fibrosis, which is applied in the field of medicine, can solve the problems of icariin in anti-pulmonary fibrosis biological activity or clinical application research, etc., to improve the therapeutic effect and quality of life, prevent Or the effect of treating pulmonary fibrosis and reducing lung index

Active Publication Date: 2019-08-13
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] But so far, there is no research on the anti-pulmonary fibrosis biological activity or clinical application of icarigenin

Method used

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  • Application of icariin in the preparation of drugs for preventing or treating pulmonary fibrosis
  • Application of icariin in the preparation of drugs for preventing or treating pulmonary fibrosis
  • Application of icariin in the preparation of drugs for preventing or treating pulmonary fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 icarigenin injection

[0018]

[0019] Preparation process: mix the prescribed amount of propylene glycol and ethanol evenly, add icariin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, that is have to.

Embodiment 2

[0020] Example 2 Icarigenin Injection

[0021]

[0022]

[0023] Preparation process: add icariin to the prescribed amount of PEG-400, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, add 0.5% activated carbon for needles, stir, decarbonize, and obtain.

Embodiment 3

[0024] Example 3 Icarigenin Injection

[0025]

[0026] Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add icariin, stir to dissolve, add water for injection to 10L, stir evenly, add 0.5% activated carbon for needles, stir, and decarbonize to obtain the product.

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Abstract

The invention relates to application of icaritin to the preparation of medicine for preventing or treating pulmonary fibrosis and belongs to the field of medicine. The icaritin is traditional Chinese medicine monomer extracted from traditional Chinese medicine epimedium. Animal experiments show that the icaritin has evident preventing and treating effects on the pulmonary fibrosis. The icaritin is definite in curative effect on the pulmonary fibrosis, low in side effect and promising in medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a medical application of icariin, in particular to the medical application of icariin in the preparation of drugs for preventing or treating pulmonary fibrosis. Background technique [0002] Pulmonary fibrosis is the final pathological change of a variety of interstitial lung diseases, characterized by long-term diffuse alveolitis, excessive proliferation of fibroblasts, and then excessive deposition of extracellular matrix, which gradually replaces normal lung tissue, eventually resulting in pulmonary fibrosis. dysfunction, the patient may die from respiratory failure. Pulmonary fibrosis can be roughly divided into two categories: known causes (such as radiation, drugs, silicosis, etc.) and unexplained causes (such as idiopathic pulmonary fibrosis). Studies have shown that various factors such as pathogenic microorganisms, dust, drugs, and chemical agents can induce pulmonary fibrosis, but...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P11/00
Inventor 赵志全孙成宏王明智齐长鹏
Owner SHANDONG NEWTIME PHARMA
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