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Method for investigation of liver damage type

An inspection method and technology for liver injury, which can be used in material inspection products, instruments, analytical materials, etc., and can solve problems such as difficult treatment policies.

Active Publication Date: 2016-03-30
DAIICHI SANKYO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinically, no clear biomarker for the early diagnosis of intrahepatic cholestasis at the capillary level has been reported so far, and it is still difficult to determine the treatment policy in many cases.

Method used

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  • Method for investigation of liver damage type
  • Method for investigation of liver damage type
  • Method for investigation of liver damage type

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] For the purpose of developing biomarkers useful for the early diagnosis of liver damage types, the concentrations of bile acid components, oxidative stress markers, and liver fibrin markers were measured using serum samples obtained from patients with liver damage and healthy volunteers . The collection of serum samples and a series of experiments were carried out with the consent of the patients and healthy volunteers as the sample providers.

[0111] 1. Target sample

[0112] Based on the approval of Daiichi Sankyo Co., Ltd. and the ethics committee of Jihui Medical University, serum was collected from 150 patients suspected of having viral, autoimmune, alcoholic, genetic, etc. liver damage within about 2 years Sample 304 sample. In addition, blood collected from volunteers was used as a serum sample derived from a healthy person. Serum samples were stored at -80°C prior to biomarker determination.

[0113] 2. Evaluation items

[0114] Determination of various bi...

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PUM

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Abstract

Provided is an investigation method for determining liver damage type, using as an indicator the concentration of lithocholic acid (hereinafter abbreviated as LCA) in a biological sample derived from a test subject. Specifically, there is provided an investigation method in which the concentration of LCA in a biological sample taken from a test subject is measured, and using the measured LCA concentration as an indicator, the type of liver damage is determined to be hematocyte damage type, cholestatic type, or a mixed type thereof.

Description

technical field [0001] The invention relates to a method for examining liver damage, in particular to a method for judging the type of liver damage. More specifically, the present invention relates to a test method for determining the type of liver damage, wherein the concentration of LCA in a biological sample collected from a test subject is measured, and the measured concentration of LCA is used as an index. Background technique [0002] The liver is a glandular tissue attached to the digestive tract. It has the functions of bile production and secretion, detoxification, glucose metabolism, protein metabolism, production of blood coagulation factors, hormone regulation, and various biological components such as fat, glycogen, protein, and vitamins. Storage and other important functions for living organisms. Therefore, when these functions are acutely or chronically injured by viral infection, excessive intake of drugs or poisons, alcohol, etc., the maintenance of the hom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N33/483
CPCG01N33/487G01N33/50G01N33/5308G01N2400/40G01N2800/085G01N2800/52H01J49/0036
Inventor 松浦知和天野克之杉田知典桝渊纪子杉原匡周
Owner DAIICHI SANKYO CO LTD
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