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Lonicera and forsythia powder micro-pill preparation and preparing method thereof

A technology of Yinqiao powder and pellets, which is applied in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems of insufficient drug efficacy, difficulty in elution of active ingredients, and low utilization rate of drugs. , to achieve the effect of making up for low bioavailability, low production cost, and simple and reliable preparation process

Inactive Publication Date: 2016-03-30
河南亚卫动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The traditional Chinese medicine Yinqiao powder is used by crushing the traditional Chinese medicine and feeding it directly. The preparation process is simple, but due to the large particle size of the medicine, there are many active ingredients that are difficult to dissolve, resulting in a low utilization rate of the medicine and a lack of efficacy. fully use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A kind of Yinqiaosan micro-pill preparation, is formulated by main medicine, auxiliary material and binding agent, and described main medicine and auxiliary material mass ratio are 1: 4, and the mass ratio of the volume of binding agent and main medicine is 6ml / g; the main drug is made of the following raw materials in parts by weight: 18 parts of honeysuckle, 14 parts of forsythia, 9 parts of peppermint, 9 parts of nepeta, 9 parts of Dandou drum, 13 parts of burdock, 7 parts of bellflower, 6 parts of bamboo leaves, 6 parts of licorice, 9 parts of reed root; auxiliary material is made up of microcrystalline cellulose, glucose, dextrin, and the weight ratio of microcrystalline cellulose, glucose, dextrin is 4: 3: 1; The agent is an ethanol solution (50% by volume).

[0019] The preparation method of the Yinqiaosan pellet preparation comprises the following steps: (1) preparation of honeysuckle, forsythia, dandougu and burdock fruit extracts: taking honeysuckle, forsythi...

Embodiment 2

[0024] A kind of Yinqiaosan micro-pill preparation, is formulated by principal agent, auxiliary material and binding agent, and the mass ratio of described principal agent and auxiliary material is 1: 3, and the mass ratio of the volume of adhesive agent and principal agent is 2ml / g; the main drug is made of the following raw materials in parts by weight: 15 parts of honeysuckle, 12 parts of forsythia, 8 parts of peppermint, 8 parts of nepeta, 8 parts of Dandou drum, 10 parts of burdock, 6 parts of bellflower, 5 parts of bamboo leaves, 5 parts of licorice, and 8 parts of reed root; the auxiliary material is mannitol, and the binder is sodium carboxymethyl cellulose solution (mass concentration is 2%).

[0025] The preparation method of the Yinqiaosan pellet preparation comprises the following steps: (1) preparation of honeysuckle, forsythia, dandougu and burdock fruit extracts: taking honeysuckle, forsythia, dandou by weight parts Drum, burdock fruit, pulverize together, add ...

Embodiment 3

[0030] A kind of Yinqiaosan micro-pill preparation, is formulated by principal agent, auxiliary material and binding agent, and the mass ratio of described principal agent and auxiliary material is 1:5, and the mass ratio of the volume of adhesive agent and principal agent is 10ml / g; the main drug is made of the following raw materials in parts by weight: 20 parts of honeysuckle, 16 parts of forsythia, 10 parts of peppermint, 10 parts of nepeta, 10 parts of light bean drum, 15 parts of burdock, 8 parts of bellflower, 7 parts of bamboo leaves, 7 parts of licorice, and 10 parts of reed root: the auxiliary material is sodium bicarbonate; the binder is sucrose solution (mass concentration 60%).

[0031] The preparation method of any one of the Yinqiao powder pellet preparations comprises the following steps: (1) preparation of extracts of honeysuckle, forsythia, dandorum, and burdock fruit: take honeysuckle, forsythia by weight , Dandougu, Burdock Fructus, pulverize together, add...

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Abstract

The invention belongs to a lonicera and forsythia powder micro-pill preparation and a preparing method thereof. The lonicera and forsythia powder micro-pill preparation is prepared from a main drug, an auxiliary material and an adhesive, the mass ratio of the main drug to the auxiliary material is 1 to (3-5), and the ratio of the volume of the adhesive to the mass of the main drug is 2-10 ml / g. The lonicera and forsythia powder micro-pill preparation has better effects of dispelling wind, relieving exterior syndrome, and clearing away heat and toxic materials; the micro-pills are round, normal and smooth, high in finished product yield, uniform in color and luster, high in hardness, and fast to dissolve, the stability of the drug is improved, moreover, slow and uniform drug releasing is maintained, the release rate of active components is reduced, besides, the toxic and side effects are also reduced, the use amount of the drug is lowered, and a clinical application effect is extended, so as to make up the defects that a traditional Chinese medicine powder has slow acting and lower biological utilization degree.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a Yinqiaosan pellet preparation and a preparation method thereof. Background technique [0002] Due to the deteriorating environment and the rapid development of the aquaculture industry, the extensive use of antibiotics, chemical synthetic drugs and hormone drugs in feed has brought great harm to aquaculture production, affecting food safety and people's health. Chinese herbal medicine is relatively safe, long-lasting, cheap and easy to get, and has dual functions of nutrition, health care and disease treatment. However, Chinese herbal medicine also has many defects, such as poor absorption and utilization, slow onset of effect and so on. [0003] Yinqiaosan is a kind of traditional Chinese medicine composed of 10 kinds of traditional Chinese medicines including honeysuckle, forsythia, mint, nepeta, light bean drum, burdock seed, pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/16A61P11/00A61P31/04A61P31/12
Inventor 赖登明张遂平郭芳茹杨慧敏吴胜耀霍新远王书丽刘诗柱马志愿刘静
Owner 河南亚卫动物药业有限公司
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