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Exhaled gas detection apparatus and uses thereof

A technology of exhaled gas and carrier gas, applied in the field of detection, can solve the problems of low detection accuracy, inability to detect trace substances in gas, etc., and achieve the effect of improving sensitivity and specificity

Inactive Publication Date: 2016-03-16
SUZHOU XIAOCI MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For this reason, the technical problem to be solved by the present invention is that the detection accuracy of the existing gas detection device is not high, and the detection of trace substances in the gas cannot be realized. material device

Method used

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  • Exhaled gas detection apparatus and uses thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] Embodiment 1 Detects the device of exhaled gas

[0022] The device for detecting exhaled gas used in this embodiment has a structure as shown in Figure 1, including a FAIMS spectrometer connected to the sample inlet port for detecting exhaled gas and a carrier gas circulation system connected in series with the FAIMS spectrometer as a loop; The gas circulation system includes: a pump that provides power for the carrier gas circulation, a mass flow controller, and a filter. As a preferred embodiment, the mass flow controller includes two mass flow controllers, namely a first mass flow controller and a second mass flow controller. The filters include activated carbon / molecular sieve filters and activated carbon filters. Wherein, the width of the chip migration channel of the FAIMS spectrometer is 35 μm.

[0023] The method of using the device in this embodiment is: the pump provides the power of the carrier gas in the carrier gas circulation system, and the carrier gas ...

Embodiment 2

[0024] Example 2 Application of the device for detecting exhaled gas-detection of lung cancer

[0025] Adopt above-mentioned device to carry out the detection of exhaled gas, comprise the following steps: at first, collect the gas exhaled by 100 healthy people, detect decanal, acetophenone, 1,3-bis(1,1-dimethyl The content of ethyl)-benzene, calculate the average value of each component content respectively as the standard control value, and calculate the standard deviation, as the healthy range value, then, take the exhaled gas to be measured and measure, when the measured value of each component is higher than or lower than When the value is within the healthy range, it is positive for lung cancer, and when it is within the healthy range, it is negative for lung cancer.

Embodiment 3

[0026] Example 3 Application of the device for detecting exhaled gas-detection of lung adenocarcinoma and lung squamous cell carcinoma

[0027] The device in Example 1 is used to detect exhaled gas, including the following steps: first, collect the exhaled gas of 100 lung adenocarcinoma patients and 100 lung squamous cell carcinoma patients, and detect 2-ethyl-1-hexyl in the exhaled gas Alcohol, 1,3-dimethyl-benzene, the amount of 1,3-bis(1,1-dimethylethyl), respectively calculate the average value of each component content, as the standard control value, and calculate the standard deviation, As the disease range value, then, take the exhaled gas to be tested for measurement, when the measured value of each component is within the range of lung adenocarcinoma, it is lung adenocarcinoma, and when the measured value of each component is within the range of lung squamous cell carcinoma, it is lung squamous cell carcinoma. cancer.

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Abstract

The present invention provides an apparatus for detecting exhaled gas and outside gas. The apparatus comprises a FAIMS spectrometer connected to a sample inlet end and used for detecting exhaled gas, and a carrier gas circulation system connected to the FAIMS spectrometer in series to form a circuit, wherein the carrier gas circulation system comprises a pump for supplying carrier gas circulation power, a quality flow rate controller and a filter, and the width of the chip migration channel of the FAIMS spectrometer is 35 [mu]m. According to the present invention, the detection limit of the apparatus can achieve 10 ppt, and the detection requirement on the trace substances in the exhaled gas can be met.

Description

technical field [0001] The invention relates to a device for detecting exhaled gas and its application, belonging to the technical field of detection. Background technique [0002] Due to the increasingly prominent environmental problems, especially the aggravation of urban smog, the incidence of lung diseases (such as lung cancer, bronchial asthma, chronic obstructive pulmonary disease, etc.) in urban population has increased sharply. Just take chronic obstructive pulmonary disease (COPD) as an example. At present, 600 million people worldwide suffer from COPD, and its prevalence rate is still rising. It is estimated that by 2020, COPD will become the third largest in the world. fatal disease. [0003] For the detection of lung diseases, the main clinical methods currently used are chest CT, magnetic resonance imaging and blood testing. Both chest CT and MRI have radiation, and blood testing also requires invasive sampling methods, which will cause certain harm to the tes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/68
Inventor 廖洁莹周辉李鹏汪小知
Owner SUZHOU XIAOCI MEDICAL TECH CO LTD
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