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High purity low molecular weight sodium chondroitin sulfate preparation technology

A technology of sodium chondroitin sulfate and low molecular weight is applied in the field of biomedical raw material preparation, which can solve the problems of unstable product quality, long production cycle, complicated process and the like, and achieve the effects of no toxic and side effects, low cost and simple process

Inactive Publication Date: 2016-03-16
QINGDAO JIULONG BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the preparation process of high-purity low-molecular-weight chondroitin sulfate sodium has long production cycle, low yield, complicated process and unstable product quality.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: the preparation technology of high-purity low molecular weight chondroitin sulfate sodium, comprises the following steps:

[0026] ① Preparation of crude low molecular weight chondroitin sulfate sodium

[0027] a. Dissolve the crude product chondroitin sulfate sodium in normal saline, after fully stirring and dissolving, add lye dropwise to the solution while stirring until precipitation occurs, filter out insoluble matter after standing to obtain chondroitin sulfate sodium solution;

[0028] b. adjust the pH of the sodium chondroitin sulfate solution obtained in step a to be 5 to 6, and cool the sodium chondroitin sulfate solution to 4° C., and add the sodium nitrite whose total weight is 1.2% of the crude product sodium chondroitin sulfate in 3 times. Add 1 / 3 of sodium nitrite at a time, add slowly and fully stir for 2 hours each time, and then add again to finally obtain crude product low molecular weight sodium chondroitin sulfate solution;

[0029] ②...

Embodiment 2

[0036] Embodiment 2: the preparation technology of high-purity low molecular weight chondroitin sulfate sodium, comprises the following steps:

[0037] ① Preparation of crude low molecular weight chondroitin sulfate sodium

[0038] a. Dissolve the crude product chondroitin sulfate sodium in normal saline, after fully stirring and dissolving, add lye dropwise to the solution while stirring until precipitation occurs, filter out insoluble matter after standing to obtain chondroitin sulfate sodium solution;

[0039] b. adjust the pH of the sodium chondroitin sulfate solution obtained in step a to be 5 to 6, and cool the sodium chondroitin sulfate solution to 1° C., and add the sodium nitrite whose total weight is 1.2% of the crude product sodium chondroitin sulfate in 3 times, every Add 1 / 3 of sodium nitrite at a time, and add after fully stirring for 3 hours, and finally get the crude product low molecular weight chondroitin sulfate sodium solution;

[0040] ②Purification of cr...

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PUM

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Abstract

The present invention discloses a high purity low molecular weight sodium chondroitin sulfate preparation technology, and the low molecular weight sodium chondroitin sulfate is prepared by preparation of a crude low molecular weight sodium chondroitin sulfate product and purifying of the crude low molecular weight sodium chondroitin sulfate product under certain conditions. Compared with the prior art, the preparation technology is simple in process, free of waste discharge and environmentally-friendly in process conditions; sources of raw materials are rich, product yield is high, product purity is high, quality is stable, cost is low, and the product is free of toxic and side effects, and can be further prepared into injections, capsules and the like.

Description

technical field [0001] The invention relates to the field of preparation of biomedical raw materials, in particular to a preparation process of high-purity and low-molecular weight chondroitin sulfate sodium. Background technique [0002] Chondroitin Sulfate Sodium is a mucopolysaccharide sulfate anticoagulant drug, which belongs to mucopolysaccharide substances. Its drug functions are mainly reflected in: treatment of various diseases complicated by early disseminated intravascular coagulation; prevention of arterial and venous thrombosis and pulmonary embolism; treatment of arterial and venous thrombosis and pulmonary embolism, ischemic stroke, unstable angina, Acute myocardial infarction; as an anticoagulant drug during artificial heart-lung, peritoneal dialysis or hemodialysis; as a maintenance treatment for thrombolytic therapy, for preventing blood coagulation during blood transfusion and for storing fresh blood in blood banks and other external anticoagulants. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08
CPCC08B37/0069C08B37/0003
Inventor 刘冠男尚明彩迟培升
Owner QINGDAO JIULONG BIO PHARMA
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