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Postoperative anesthetic anodyne and preparation method and application thereof

An analgesic and analgesic drug technology, applied in the field of postoperative anesthesia analgesics and its preparation, can solve the problems of high price, affecting sleep quality, unfavorable conditions, etc., so as to reduce the incidence of complications and improve the success and safety. , the effect of improving dependencies

Inactive Publication Date: 2016-03-16
庄小侃
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For wound pain after surgery, patients are generally given analgesic pumps in clinical practice. Western medicine anesthetics are added to the pumps, but the western medicines in the analgesic pumps are expensive, which puts a high financial burden on patients; secondly, the analgesic pump needs to be worn on the back , the patient can only lie on his side, which affects the quality of sleep. Finally, improper use of western medicine can easily cause side effects such as vomiting, drowsiness, urinary retention, and skin itching.

Method used

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  • Postoperative anesthetic anodyne and preparation method and application thereof
  • Postoperative anesthetic anodyne and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of hibiscus leaf extract dry powder

[0013] (1) Weigh 1.12kg of dried hibiscus leaves, grind them to an average particle size of 0.3-0.5mm, add ethanol with a volume concentration of 60% as an extractant according to the ratio of solid to liquid 1kg: 18L, shake and extract at room temperature for 30h, and separate the supernatant liquid, and the supernatant was concentrated under reduced pressure of 0.08MPa to recover ethanol, and continued to concentrate and dry to obtain ethanol extract;

[0014] (2) Disperse the above-mentioned ethanol extract in distilled water, the ratio of solid to liquid is 1g: 30ml, then add ethyl acetate in a volume ratio of 1: 2 and shake and extract for 3 times, collect the ethyl acetate phase extract and the aqueous phase extract, Concentrate and dry respectively to obtain hibiscus leaf extract, pulverize and pass through a 100-mesh sieve to obtain dry extract powder.

Embodiment 2

[0015] Example 2: Research on the Analgesic Effect of Hibiscus Leaf Extract on Pain Induced by Hot Plate

[0016] 47 healthy female Kunming mice were placed in a hot plate at 55°C in turn, and the time (s) required from putting the hot plate to licking the hind paw was observed and recorded. The time for licking the hind paw was 30s or jumped Those who discard it are not used. The mice that passed the screening were selected, and the pain threshold was re-measured once after an interval of 5 minutes, and the average value of the data measured twice was used as the pain threshold before administration. According to the pain threshold before administration, they were randomly divided into the following four groups: model control group, positive control group, test A group and test B group. After the test started, the positive control group was given aspirin 200mg / kg by intragastric administration, the ethyl acetate phase extract dry powder 716mg / kg prepared in Example 1 was adm...

Embodiment 3

[0021] Embodiment 3: the analgesic test of extract to the writhing reaction of mice induced by acetic acid

[0022] There were 24 Kunming mice, weighing 18-22 g, half male and half male. The dosage of each mouse was determined according to body weight, and all mice were randomly divided into a low-dose extract group, a high-dose extract group, and a model control group, with 8 mice in each group. After the start of the test, the low-dose and high-dose extract groups were continuously orally administered 358 and 716 mg / kg of the ethyl acetate phase extract dry powder prepared in Example 1, once a day. After 1 hour of the last administration, each mouse was injected with 0.6% acetic acid solution 0.2ml / 10g intraperitoneally respectively, and the writhing reactions (abdominal contraction and indentation, stretching of hind limbs, buttocks raising, creeping) occurred in each group within 15 minutes after injection of acetic acid solution were observed and recorded. ) of each mous...

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Abstract

The invention discloses a postoperative anesthetic anodyne and a preparation method and application thereof. The anodyne is ethyl acetate extract of hibiscus syriacus L. leaves, can effectively relieve pains of patients, decrease the occurrence rate of complications and improve success and safety of operations, is convenient to use and low in toxic and side effects and can improve medicine dependence of patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine nursing, and in particular relates to a postoperative anesthesia analgesic and its preparation method and application. Background technique [0002] For wound pain after surgery, patients are generally given analgesic pumps in clinical practice. Western medicine anesthetics are added to the pumps, but the western medicines in the analgesic pumps are expensive, which puts a high financial burden on patients; secondly, the analgesic pump needs to be worn on the back , The patient can only lie on his side, which affects the quality of sleep. Finally, improper use of western medicine can easily cause side effects such as vomiting, drowsiness, urinary retention, and skin itching. Therefore, need a kind of new anesthesia with cheap price and analgesic effect good and lasting operation incision anesthesia analgesic service to numerous patients. Contents of the invention [0003] T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P23/00A61P29/00A61K127/00
CPCA61K36/185A61K2236/333A61K2236/51A61K2236/53
Inventor 不公告发明人
Owner 庄小侃
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