Cerebral edema treating pharmaceutical composition and uses thereof
A composition and brain edema technology, applied in the field of medicine, can solve problems such as pain, injection site irritation, lack of consensus, etc., and achieve the effect of reducing damage, reducing dosage, and consolidating the therapeutic effect
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Embodiment 1
[0027] The preparation of embodiment 1 compound tablet
[0028]
[0029] Preparation process: mix oxiracetam and ethacrylic acid with auxiliary materials microcrystalline cellulose and starch evenly, add an appropriate amount of 15% starch to make soft material, and pass through a 16-mesh sieve to granulate. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve for granulation, added with sodium carboxymethyl starch and magnesium stearate, mixed evenly, and pressed into tablets to obtain the product.
Embodiment 2
[0030] The preparation of embodiment 2 compound tablet
[0031]
[0032]
[0033] Preparation process: mix oxiracetam and ethacrynic acid with auxiliary materials lactose and compressible starch evenly, add appropriate amount of 15% starch slurry to make soft material, and then granulate through a 16-mesh sieve. The wet granules are dried at 60°C, the dry granules are sieved through a 16-mesh sieve for granulation, added with croscarmellose sodium and micropowder silica gel, mixed evenly, and pressed into tablets to obtain the product.
Embodiment 3
[0034] The preparation of embodiment 3 compound dispersible tablets
[0035]
[0036] Preparation process: Weigh oxiracetam and ethacrynic acid according to the prescription, use microcrystalline cellulose as filler, cross-linked sodium carboxymethyl cellulose and cross-linked polyvinylpyrrolidone as disintegrants, 5% PVP k30 60% ethanol solution is used as binder, micronized silica gel is used as flow aid, granulated in one step in a fluidized bed, then added with magnesium stearate, mixed evenly, and pressed into tablets to obtain the product.
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