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Antibacterial material with pH responsivity and light sensitivity and preparation method thereof

An antibacterial material and responsive technology, applied in the field of antibacterial materials with pH responsiveness and photosensitivity and its preparation, to achieve low cost, good biocompatibility, and the effect of improving biological effects

Active Publication Date: 2016-03-09
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is still a need for improvement in the targeting of bacterial infections.

Method used

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  • Antibacterial material with pH responsivity and light sensitivity and preparation method thereof
  • Antibacterial material with pH responsivity and light sensitivity and preparation method thereof
  • Antibacterial material with pH responsivity and light sensitivity and preparation method thereof

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Embodiment Construction

[0038] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0039] An antibacterial material with pH responsiveness and photosensitivity is that hydrophilic and hydrophobic photodynamic molecules are loaded into nanoparticle polymer Poly(HDDA-co-DBPA)-PEG.

[0040] The polymer Poly(HDDA-co-DBPA)-PEG is a nanoparticle made by addition of HDDA, DBPA, and mPEG monomers; wherein the molar ratio of HDDA:DBPA:mPEG is (1~1.5)( 0.8~1.2): (0.08~0.15).

[0041] The structural formula of the polymer Poly(HDDA-co-DBPA)-PEG is:

[0042]

[0043] Wherein, R is an alkyl group. Specifically, R is butyl or ethyl.

[0044] Such as figure 1 Shown is a schematic diagram of the structure of the antibacterial material when the photodynamic molecule Chlorine6 is hydrophilic and hydrophobic.

[0045] see figure 2 , the preparation method of the above-mentioned anti...

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Abstract

The invention discloses an antibacterial material with pH responsivity and light sensitivity and a preparation method thereof. Hydrophilic and hydrophobic photodynamic molecules are loaded in a nano particle polymer Poly(HDDA-co-DBPA)-PEG. High molecular polymer nano particles with pH responsivity are prepared and are subjected to hydrophilic PEG modification, and photodynamic molecule medicines Chlorin e6 are loaded into the nano particles by hydrophilic and hydrophobic properties. Multiple biological antibacterial technologies are integrated, the bactericidal biological effect is increased, the adhesion of medicines in special environments is effectively increased, the bacterial organism growth is inhibited, an effective antibacterial effect can be achieved, the biocompatibility is good, the cost is low, and the material stability is good. A biological macromolecular antibacterial material obtained by the preparation method disclosed by the invention has the characteristics of effective antibacterial effect, good biocompatibility, good stability and low cost.

Description

technical field [0001] The invention belongs to the technical field of antibacterial materials, and relates to an antibacterial material with pH responsiveness and photosensitivity and a preparation method thereof. Background technique [0002] Catheter-associated urinary tract infection (CAUTI) caused by indwelling catheter is the most common nosocomial infection in clinical practice, ranking first in the United States and second in my country. For patients with long-term indwelling catheters, the incidence of bacteriuria is almost 100%. Related infections not only cause a lot of waste of medical resources, but also seriously affect the recovery of patients, and even threaten their lives. Therefore, urinary system infection caused by indwelling catheter has become a major clinical problem that needs to be solved urgently. [0003] In recent years, in order to prevent the occurrence of urinary system infection, the research and development of medical urinary system-related ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/34A61K9/51A61P31/04A61P13/00
Inventor 刘仕杰邵晨王浩
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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