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A kind of florfenicol soluble powder and preparation method thereof

A florfenicol and soluble technology, which is applied in the field of florfenicol soluble powder and its preparation, can solve the problems of difficulty in meeting preparations and concentrated formulations, unsatisfactory solubilization effect, slow dissolution speed, etc. The effect of production and promotion, easy drinking water administration, and low production cost

Active Publication Date: 2018-07-17
武汉回盛生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, my country's florfenicol water-soluble technology mainly consists of solubilizing method, solid dispersion method, ultramicro, etc., but the solubilizing effect of these methods is not ideal, the dissolution rate is slow, and the dissolution rate is small, which is difficult to meet the requirements of preparations and concentrated formulations. need

Method used

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  • A kind of florfenicol soluble powder and preparation method thereof
  • A kind of florfenicol soluble powder and preparation method thereof
  • A kind of florfenicol soluble powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A kind of florfenicol soluble powder, its preparation method is as follows:

[0027] 1) Add 20 g of florfenicol powder bulk drug and 5 g of poloxamer 188 into 250 g of sodium hydroxide solution with pH=8.5, stir for 15 min, and mix well to obtain mixture A.

[0028] 2) Add 1g of dopamine hydrochloride to mixture A, continue to stir for 1 hour to obtain mixture B, spray and dry mixture B, control the inlet air temperature to 170°C, the outlet air temperature to 85°C, and the peristaltic pump speed to 140rpm to obtain a powder The florfenicol polydopamine complex has been tested, and the drug loading capacity of the florfenicol polydopamine complex is 65.4%, and the encapsulation rate is 95.2%.

[0029] 3) Calculate the weight ratio of glucose to the florfenicol polydopamine complex according to the drug loading of the florfenicol polydopamine complex and the content of the florfenicol in the prepared florfenicol soluble powder.

[0030] 4) Weigh the glucose and the Flor...

Embodiment 2

[0032] A kind of florfenicol soluble powder, its preparation method is as follows:

[0033] 1) Add 20 g of florfenicol powder bulk drug and 5 g of Tween 80 into 250 g of sodium hydroxide solution with pH=8.5, stir for 15 min, and mix well to obtain mixture A.

[0034] 2) Add 1 g of dopamine hydrochloride to mixture A, continue to stir for 0.5 hours to obtain mixture B, spray and dry mixture B, control the inlet air temperature to 180°C, the outlet air temperature to 80°C, and the peristaltic pump speed to 140rpm to obtain a powder The florfenicol polydopamine complex has been tested, and the drug loading capacity of the florfenicol polydopamine complex is 61.8%, and the encapsulation efficiency is 88.5%.

[0035] 3) Calculate the weight ratio of glucose to the florfenicol polydopamine complex according to the drug loading of the florfenicol polydopamine complex and the content of the florfenicol in the prepared florfenicol soluble powder.

[0036] 4) Weigh the glucose and the...

Embodiment 3

[0038] A kind of florfenicol soluble powder, its preparation method is as follows:

[0039] 1) Add 20 g of florfenicol powder bulk drug into 250 g of sodium hydroxide solution with pH=8.5, stir for 15 min, and mix well to obtain mixture A.

[0040] 2) Add 1 g of dopamine hydrochloride to mixture A, continue to stir for 2 hours to obtain mixture B, spray and dry mixture B, control the inlet air temperature to 160°C, the outlet air temperature to 90°C, and the peristaltic pump speed to 140rpm to obtain a powder The florfenicol polydopamine complex has been tested, and the drug loading capacity of the florfenicol polydopamine complex is 55.7%, and the encapsulation efficiency is 80.4%.

[0041] 3) Calculate the weight ratio of glucose to the florfenicol polydopamine complex according to the drug loading of the florfenicol polydopamine complex and the content of the florfenicol in the prepared florfenicol soluble powder.

[0042] 4) Weigh the glucose and the Florfenicol polydopam...

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Abstract

The invention discloses florfenicol soluble powder and a preparation method thereof. The soluble powder is composed of a florfenicol polydopamine compound and a substrate diluent. A preparation method of the florfenicol polydopamine compound comprises the following steps that 1, a surface active agent and florfenicol are added to an alkalescent solution and evenly mixed to obtain a mixture A, wherein the surface active agent can be added or not added; 2, dopamine hydrochloride is added to the mixture A, stirring is continuously conducted, a mixture B is obtained, spray drying is conducted, and the florfenicol polydopamine compound is obtained. The preparation method of the florfenicol soluble powder comprises the steps that 1, the substrate diluent and the florfenicol polydopamine compound are weighed through calculation, then the florfenicol polydopamine compound and the substrate diluent are mixed to be uniform, and the florfenicol soluble powder is obtained. The florfenicol soluble powder contains the florfenicol polydopamine compound, solubility of the florfenicol can be effectively improved, and the dissolving-out speed can be increased. The method is simple and easy to carry out, the time needed in preparation is short, and the production energy consumption is small.

Description

technical field [0001] The invention relates to the technical field of veterinary antibiotic preparations, in particular to a florfenicol soluble powder and a preparation method thereof. Background technique [0002] Florfenicol is a new generation of chloramphenicol-type veterinary-specific broad-spectrum antibiotics. It has the characteristics of broad antibacterial spectrum, good absorption, wide distribution in the body, high efficiency and safety, etc. It has a significant therapeutic effect on poultry bacterial diseases caused by sensitive bacteria. Lambert-positive bacteria and negative bacteria have effects, and it is the drug of choice for various infections caused by typhoid bacillus, paratyphoid bacillus and salmonella. Because chloramphenicol has serious adverse reactions of aplastic anemia, it has been banned from being used in food animals. Therefore, florfenicol has broad application prospects in the prevention and treatment of animal diseases, especially in f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/165A61K47/34A61P31/04
CPCA61K9/0095A61K9/146A61K31/165
Inventor 张卫元李子彬唐万勇丁文格张翠平张永丹刘治滨朱秀高余虎杰黄文辉
Owner 武汉回盛生物科技股份有限公司
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