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Preparation method of slow-release sparfloxacin injection

A technology for slow-release sefloxacin and sefloxacin, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc. problem, to achieve the effect of prolonging the release time

Inactive Publication Date: 2016-03-02
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the defects of the prior art, and provides a preparation method capable of prolonging the half-life of spafloxacin injection, so as to solve the need for repeated medication in the treatment process of medium and long-duration animal diseases in the prior art, and increase the emergency response of animals. and the problem of increasing the cost of farming

Method used

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  • Preparation method of slow-release sparfloxacin injection

Examples

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Effect test

Embodiment 1

[0027] Preparation of 5% spafloxacin n-hexanoate injection

[0028] Take 5g of spafloxacin (purified) and 40g of N,N-dimethylacetamide, stir and dissolve until clear, add 1g of n-hexanoic acid and slowly stir for complexation for 1h, add 5g of fatty acid glycerides and continue to stir until clear, N,N -Dimethylacetamide was adjusted to 100ml, and filtered through a 0.45 μm organic membrane to obtain 5% spafloxacin injection.

Embodiment 2

[0030] Preparation of 10% spafloxacin laurate injection

[0031] Take 10g of spafloxacin (reduced pure) and 40g of propylene glycol, stir and dissolve until clear, add 2g of lauric acid and slowly stir for complexation for 2h, add 10g of glycerin fatty acid ester and continue to stir until clear, propylene glycol to 100ml, use 0.45μm Filter through an organic membrane to obtain 10% spafloxacin laurate injection.

Embodiment 3

[0033] Preparation of 15% spafloxacin palmitate injection

[0034] Take 15g of spafloxacin (pure) and 40g of 2-pyrrolidone, stir and dissolve until clear, add 3g of palmitic acid and slowly stir for complexation for 3h, then add 20g of polyvinylpyrrolidone and continue stirring until clear, and the volume of 2-pyrrolidone to 100ml, filtered through a 0.45μm organic membrane to obtain 15% spafloxacin palmitate injection.

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Abstract

The invention provides a preparation method of a slow-release sparfloxacin injection and relates to a slow-release injection for animals. The sparfloxacin injection comprises components in percentage by weight as follows: 5%-20% of sparfloxacin, 1%-4% of fatty acid, 5%-35% of a stabilizer and the balance of an organic solvent. The sparfloxacin and the organic solvent are taken and stirred to be dissolved, the fatty acid is added to have a complex reaction with a dissolution product, the stabilizer is added and fully dissolved, the organic solvent is added until the mixture reaches a certain volume and is subjected to membrane filtration, and the slow-release sparfloxacin injection is prepared. New composition is formed after sparfloxacin, salt of sparfloxacin or hydrate of sparfloxacin has a reaction with the fatty acid, the release time of sparfloxacin can be prolonged, the effective blood concentration of the medicine in the animals is maintained for a long time, and accordingly, the purposes of reducing administration frequency and stress due to the medicine are achieved.

Description

technical field [0001] The invention relates to a preparation method of veterinary injection, in particular to a preparation method of sustained-release spafloxacin injection. Background technique [0002] Sparfloxacin (sparfloxacin) has a broad antibacterial spectrum, and its antibacterial activity against Gram-negative bacteria is similar to that of ciprofloxacin. , and is also effective against a variety of drug-resistant bacteria. After oral absorption, it has a high concentration in the tissue and a long half-life. It is used for the infection of sensitive bacteria, anaerobic bacteria, mycoplasma and chlamydia. In addition to having high antibacterial activity against Gram-negative bacilli, it also has good antibacterial effect on Staphylococcus, and its effect on Pneumococcus and Streptococcus is slightly worse than that of Staphylococcus. The product also has inhibitory effect on some mycobacteria, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, e...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/496A61K47/18A61K47/14A61K47/32A61K47/44A61P31/04
CPCA61K9/08A61K31/496A61K47/14A61K47/18A61K47/32A61K47/44
Inventor 董萌萌付旭彬杨保收梁武
Owner TIANJIN RINGPU BIO TECH
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