Extracting method of Chinese toon seed polyphenols and uses of the polyphenols for treating Parkinson disease

A technology of Chinese toon seed polyphenols and extraction method, which is applied in the field of natural product extraction technology, can solve problems such as inconvenience, and achieve the effect of treating Parkinson's disease

Active Publication Date: 2016-02-24
WEIFANG MEDICAL UNIV
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[0007] In summary, there are obviously inconveniences and defects in

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  • Extracting method of Chinese toon seed polyphenols and uses of the polyphenols for treating Parkinson disease
  • Extracting method of Chinese toon seed polyphenols and uses of the polyphenols for treating Parkinson disease
  • Extracting method of Chinese toon seed polyphenols and uses of the polyphenols for treating Parkinson disease

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[0039] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0040] The invention provides a method for extracting polyphenols from Toona sinensis, which comprises the following steps: step A: crushing the seeds of Toona sinensis, and passing through a drug sieve to obtain medicinal powder of Chinese toon seeds; step B: adding petroleum ether to the obtained medicinal powder of Chinese toon seeds, Water-bath reflux extraction to obtain medicinal residues, volatilize the solvent in the medicinal residues, and then perform low-temperature drying treatment, so that the water content of the medicinal residues is controlled at 3%; step C: put the Chinese toon seed...

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Abstract

The invention relates to the technical field of extraction processes of natural products, and provides an extracting method of Chinese toon seed polyphenols and uses of the polyphenols for treating Parkinson disease. The method includes steps of A) smashing Chinese toon seeds, and sieving with a medicinal sieve to obtain Chinese toon seed powder, B) adding the obtained Chinese toon seed powder into petroleum ether, performing reflux extraction with water bath under atmospheric pressure to obtain medicine dregs, allowing solvents in the medicine dregs to evaporate, and drying at low temperature to control the water content of the medicine dregs to be 3%, and C) processing the Chinese toon seed medicine dregs obtained in the step B) in an ultrasonic biomixer, adding ethanol, and extracting the Chinese toon seed polyphenols. The Chinese toon seed polyphenols can be efficiently extracted by the method. The Chinese toon seed polyphenols have a plurality of biological functions, such as oxidation resistance, anti-inflammatory functions, antineoplastic functions, nerve protection, anti-hypertension functions and antidiabetic functions, and have certain effects on treatment of the Parkinson disease.

Description

technical field [0001] The invention relates to the field of natural product extraction technology, in particular to a method for extracting polyphenols from Toona sinensis and its application in treating Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is a degenerative disease of the central nervous system that seriously endangers the health of middle-aged and elderly people. Its main pathological changes are progressive degeneration and death of dopamine (DA) neurons in the substantia nigra of the midbrain , 70-80% has been lost when clinical symptoms appear, and the remaining neurons continue to degenerate, resulting in a significant reduction in the content of DA, the characteristic neurotransmitter of PD, in the striatum. In addition to motor symptoms such as resting tremor, muscle stiffness, slowing of voluntary movement, and abnormal posture and gait, it is also accompanied by non-motor symptoms (NMS), including sensory disturbance, sleep d...

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Application Information

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IPC IPC(8): A61K36/58A61P25/16
Inventor 付文玉庄文欣吕娥李万忠李锋杰
Owner WEIFANG MEDICAL UNIV
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