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Beagle spinal cord orientation channel stent and production method thereof

A beagle and spinal cord technology, applied in the field of beagle spinal cord directional channel support and its preparation based on three-dimensional printing technology, can solve problems such as spatial structure gap, and achieve the promotion of nerve regeneration, clear effect, strong self-renewal and proliferation ability Effect

Inactive Publication Date: 2016-02-24
THE CHINESE PEOPLES ARMED POLICE LOGISTICS INST AFFILIATED HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the spatial structure of the tissue engineering scaffold prepared by the current technology is quite different from that of the spinal cord in vivo.

Method used

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  • Beagle spinal cord orientation channel stent and production method thereof
  • Beagle spinal cord orientation channel stent and production method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 Beagle spinal cord directional channel support

[0027] like figure 1 , 2 As shown, a Beagle spinal cord directional channel support includes a support body 1, a Beagle spinal cord directional channel support includes a support body 1, and the inside of the support body 1 is provided with thin bundles, wedge bundles, and spinothalamic bundles. , lateral corticospinal tract, posterior spinocerebellar tract, lateral spinothalamic tract, tectum of the spinal cord, anterior spinothalamic tract, anterior corticospinal tract, and the hollow area of ​​gray matter; the hollow area 2 for growing thin and wedge tracts is located in the The upper part of the stent body 1; the hollow area 3 for growing gray matter is located at the center of the stent body 1; the hollow area 4 for growing the posterior spinocerebellar tract, the hollow area 5 for growing the lateral spinothalamus tract, There are two hollow areas 7 for growing the lateral corticospinal tract, two hol...

Embodiment 2

[0032] Embodiment 2 Preparation of Beagle Spinal Cord Oriented Channel Support

[0033] (1) According to the actual situation of the Beagle spinal cord, understand the diameter and course of the thin tracts, wedge tracts, corticospinal tracts, spinothalamic tracts, and spinocerebellar tracts, and design a 3D model of the Beagle spinal cord directional channel bracket, and the file is in STL format; Import the design model of the spinal cord directional channel bracket into the 3D bioprinter computer, and the printer software will convert the data of the model by itself;

[0034](2) In this embodiment, silk fibroin is used as the biological material of the spinal cord directional channel scaffold. Silk fibroin is prepared from silkworm cocoon silk by degumming, dissolving, dialysis and concentration methods. Put the silkworm cocoon silk at 80-120°C Na 2 CO 3 degumming in a solution of CaCl 2 , ethanol, and water solution for 2-5h, dialyzed in a dialysis bag under running wat...

Embodiment 3

[0038] Example Three Beagle Spinal Cord Oriented Channel Scaffold Preparation

[0039] (1) According to the actual situation of the Beagle spinal cord, understand the diameter and course of the thin tracts, wedge tracts, corticospinal tracts, spinothalamic tracts, and spinocerebellar tracts, and design a 3D model of the Beagle spinal cord directional channel bracket, and the file is in STL format; Import the design model of the spinal cord directional channel bracket into the 3D bioprinter computer, and the printer software will convert the data of the model by itself;

[0040] (2) In this embodiment, silk fibroin eggs and hydroxyapatite are used as the biomaterials of the spinal cord directional channel scaffolds, and are prepared by degumming, dissolving, dialysis and concentration methods, and silkworm cocoons are placed in 80-120°C Na 2 CO 3 degumming in a solution of CaCl 2 , ethanol, water (1:2:8) solution for 2-5h to dissolve, then dialyze in a dialysis bag under runn...

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Abstract

The invention provides a beagle spinal cord orientation channel stent which comprises a stent body. A hollow area for growing fasciculus gracilis, fasciculus cuneatus, tractus spinothalamicus, tractus corticospinalis lateralis, fasciculus cerebellospinalis, tractus spinothalamicus lateralis, tractus spinotectalis, tractus spinothalamicus anterior, direct pyramidal tract and grey matter is arranged inside the stent body. The stent body is 8-15mm in vertical diameter, 6-10mm in transverse diameter and 0.1-1.0mm in wall thickness. The beagle spinal cord orientation channel stent based on the three-dimensional printing technology has the advantages that the precision and structure problems in the prior art can be solved, and the beagle spinal cord orientation channel stent is applicable to treatment and researches of spinal cord injuries.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to a beagle spinal cord directional channel bracket based on three-dimensional printing technology and a preparation method thereof. Background technique [0002] The sensory and motor dysfunction caused by spinal cord injury is a major unsolved problem in the medical field. Spinal cord regeneration is difficult to solve. On the one hand, due to the limited regeneration ability of nerve cells in the spinal cord, the dead cells cannot be replenished by nerve cell proliferation; on the other hand, the microenvironment that inhibits nerve regeneration is formed at the injured site, mainly including the following aspects: Damaged cells produce a large number of factors that inhibit axon growth; the damaged site lacks neurotrophic factors that promote cell growth; lacks the support of relevant glial cells to guide the growth of neuron axons; scar tissue forms at the defe...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61L27/38A61L27/54A61L27/58A61L27/24A61L27/22A61L27/12A61L27/20A61L27/18
Inventor 涂悦陈旭义卢磊张赛李瑞欣汤锋武程远驰刚琳杨凯李一鹏
Owner THE CHINESE PEOPLES ARMED POLICE LOGISTICS INST AFFILIATED HOSPITAL
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