Treatment of lung and other conditions

Abstract

Disclosed herein is a compound, or a pharmaceutically acceptable salt or ester thereof, having the structure X1-L-X2, wherein L is a linking moiety comprising an enone; and X1 and X2 are each independently optionally substituted N ‑ Heterocycle. Also disclosed herein are methods of treating lung disorders and disorders of other organs or systems with the compounds.

Description

[0001] This application claims the benefit of US Provisional Application No. 61 / 822,224, filed May 10, 2013, which is hereby incorporated by reference in its entirety. [0002] Confirmation of government support [0003] This invention was made with government support under Grant No. HL093196 awarded by the National Institutes of Health. The government has certain rights in this invention. Background technique [0004] The lungs are organs that rely on delicate structures, such as the alveolar-capillary interface for important gas exchange functions, but are often exposed to toxins and irritants in inhaled gases. It can also be damaged by toxins and inflammatory products produced by infection and by misplacement elsewhere in the body. As a result, the lung is subject to a wide variety of diseases, many of which have a pathogenesis that is not fully understood. Some of these diseases and conditions have effective treatments available; these treatments may include the adminis...

AI Technical Summary

Problems solved by technology

Like other environmental carcinogens that can induce lung cancer, the carcinogens in cigarette smoke cause mutations that cause the affected cells to proliferate uncontrollably and also allow them to invade normal tissues

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