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Method for preparing siwu decoction formula granules and quality control method thereof

A technology of formula granules and Siwutang, which is applied in the field of preparation of Siwutang formula granules, achieves the effects of fast analysis speed, low moisture absorption and guaranteed product quality

Active Publication Date: 2016-02-03
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In China, hundreds of single-flavored formula granules have been launched, but because the current Chinese medicine formula granules are all single-flavored Chinese herbal extracts, people worry about "co-decoction" and "separate decoction". difference problem

Method used

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  • Method for preparing siwu decoction formula granules and quality control method thereof
  • Method for preparing siwu decoction formula granules and quality control method thereof
  • Method for preparing siwu decoction formula granules and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] A preparation method of Siwutang formula granules, comprising the steps of:

[0060] a. Take Rehmannia glutinosa 550g, Angelica sinensis 550g, Baishao 550g, Chuanxiong 550g, add 17.6kg of water, decoct and extract for 1 hour, that is, decoct once; after decocting, add 13.2kg of water to the dregs, decoct and extract for 1 hour, That is, the second decoction; during the two decoction extraction process, the aromatic water is collected;

[0061] b. Combine the two decoction filtrates, filter, and concentrate the filtrate under reduced pressure under vacuum to a concentrated solution with a relative density of 1.06 at 60°C;

[0062] c. Take the above concentrated solution and add β-cyclodextrin and silicon dioxide (bulk density is 0.15g / ml). The amount accounts for 0.8% of the weight of the solid content of the concentrated solution, and the clear paste is obtained after stirring evenly;

[0063] d. Mix the aromatic water and clear paste, then spray dry, control the air ...

Embodiment 2

[0067] A preparation method of Siwutang formula granules, comprising the steps of:

[0068] a. Take rehmannia glutinosa 1000g, angelica 900g, white peony root 800g, chuanxiong 800g, add 28.0kg of water, decoct and extract for 1.5 hours, that is, first fry; after the first decoction, add 21.0kg of water to the dregs, decoct and extract for 1 hour, That is, the second decoction; during the two decoction extraction process, the aromatic water is collected;

[0069] b. Combine the two decoction filtrates, filter, and concentrate the filtrate under reduced pressure under vacuum to a concentrated solution with a relative density of 1.07 at 60°C;

[0070] c. Take the above concentrated solution and add β-cyclodextrin and silicon dioxide (bulk density is 0.20g / ml). The amount accounts for 0.8% of the weight of the solid content of the concentrated solution, and the clear paste is obtained after stirring evenly;

[0071] d. Mix the aromatic water and clear paste, then spray dry, cont...

Embodiment 3

[0075] A preparation method of Siwutang formula granules, comprising the steps of:

[0076] a. Take 250g of rehmannia glutinosa, 250g of angelica, 200g of white peony root, 200g of Chuanxiong, add 9.0kg of water, decoct and extract for 1 hour, that is, first fry; after the first decoction, add 7.2kg of water to the dregs, decoct and extract for 1 hour, That is, the second decoction; during the two decoction extraction process, the aromatic water is collected;

[0077] b. Combine the two decoction filtrates, filter, and concentrate the filtrate under reduced pressure under vacuum to a concentrated solution with a relative density of 1.05 at 60°C;

[0078] c. Take the above concentrated solution and add β-cyclodextrin and silicon dioxide (bulk density is 0.18g / ml). The amount accounts for 0.5% of the weight of the solid content of the concentrated solution, and the clear paste is obtained after stirring evenly;

[0079] d. Mix the aromatic water and clear paste, then spray dry...

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Abstract

The invention discloses a method for preparing siwu decoction formula granules and a quality control method thereof. The method for preparing the siwu decoction formula granules comprises steps: prepared rehmannia roots, angelica sinensis, radix paeoniae alba and ligusticum wallichii medicinal slices are added with water which is 5-15 times of the weight of total inventory, are extracted for two times, aromatic water is collected and is combined with two frying filter liquids, are decompressed and concentrated in vacuum, a concentrated solution is added with beta (Beta)-cyclodextrin and silicon dioxide to uniformly stir and obtains a clear paste, and the aromatic water and the aromatic water are sprayed and dried after being uniformly mixed, and are pelletized through a dry method to prepare the siwu decoction formula granules. The quality control method of the siwu decoction formula granules comprises qualitative identification of an infrared fingerprint spectrum and a thin layer and content determination of a high performance liquid chromatography (HPLC). The method for preparing siwu decoction formula granules and the quality control method thereof decoct in a combined mode according to a traditional method, can perfectly take full advantages of drug matching compared with an existing method that various medicinal odours are added when single formula particles are taken, reflects the overall concept of Chinese medicine, guarantees to achieve the purpose of reducing toxicity and enhancing efficacy, supplies novel selection for clinical medication, builds a perfect quality standard, controls quality by combining a power-spectral method and a chromatography, and can effectively control quality of complex granules from the overall to the more specific.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and in particular relates to a preparation method of Siwu Decoction formula granules and a quality control method thereof. Background technique [0002] Siwu Decoction is composed of rehmannia glutinosa, angelica, white peony root, and chuanxiong four-flavored decoction pieces. It is a famous prescription for treating "blood deficiency and stagnation". "Taiping Huimin Heji Bureau Prescription" first recorded Siwu Decoction in treating obstetrics and gynecology diseases, and expanded its clinical application. There are only 4 medicines in Siwu Decoction, but the medicine is simple and concise, with stable efficacy, and it is the basic prescription for treating blood syndrome. Rehmannia glutinosa in the prescription is sweet and slightly warm in nature, moist and greasy in texture, and is an important medicine for nourishing yin and blood. Angelica is sweet, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/16A61K47/40A61P7/06G01N21/3563G01N30/02G01N30/90
Inventor 谭登平官永河霍文杰杜兰哲钟华林赵径华
Owner GUANGDONG YIFANG PHARMA
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