Pharmaceutical composition overcoming postoperative sleep disorder
A technology for sleep disorders and compositions, applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, can solve problems such as aggravating sleep disorders, failing to improve sleep structure, etc., achieving no side effects, prolonging total sleep time, The effect of improving sleep efficiency
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Embodiment 1
[0069] 1. Preparation of pharmaceutical composition
[0070] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 4ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 4ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.
[0071] 2. Medication for patients
[0072] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients, who were 76 elderly patients aged 65 or over who were admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation.
[0073] Inject the 4ug / ml dexmedetomidine solution obtai...
Embodiment 2
[0076] 1. Preparation of pharmaceutical composition
[0077] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 2ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 2ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.
[0078] 2. Medication for patients
[0079] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients who were 65 years old or older and admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation.
[0080] The 4ug / ml dexmedetomidine solution obtained in step 1 was injected ...
Embodiment 3
[0083] 1. Preparation of pharmaceutical composition
[0084] Dexmedetomidine was diluted with 0.9% sodium chloride solution to make the concentration 6ug / ml. Specifically, it may be that commercially available dexmedetomidine solution is added to 48ml of 0.9% sodium chloride injection to form a solution with a total volume of 50ml, and the chlorine solution added with dexmedetomidine solution is gently shaken. Sodium chloride injection was uniformly mixed to obtain a dexmedetomidine solution with a concentration of 6ug / ml. It should be noted that strict aseptic technique must be maintained throughout the operation.
[0085] 2. Medication plan
[0086] A small randomized, randomized, double-blind, placebo-controlled experimental study was conducted on elderly patients who were 65 years old or older and admitted to the ICU after non-cardiac surgery and did not require mechanical ventilation.
[0087] The 4ug / ml dexmedetomidine solution obtained in step 1 was injected into the...
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