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A Measuring System of Neuron Phase Response Characteristics Based on Firing Rate Clamping Closed Loop

A measurement system and neuron technology, applied in the field of biomedical engineering, can solve problems such as wasting measurement results, achieve accuracy, improve experiment efficiency, and save experiment time

Inactive Publication Date: 2017-11-21
TIANJIN UNIV
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Problems solved by technology

In the traditional measurement method, it takes a long time to wait for the cells to reach a stable discharge state, and it is necessary to avoid the influence of various disturbances during the discharge interval during the measurement process, wasting a lot of measurement results

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  • A Measuring System of Neuron Phase Response Characteristics Based on Firing Rate Clamping Closed Loop
  • A Measuring System of Neuron Phase Response Characteristics Based on Firing Rate Clamping Closed Loop
  • A Measuring System of Neuron Phase Response Characteristics Based on Firing Rate Clamping Closed Loop

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Embodiment Construction

[0022] The measurement system of the neuron phase response characteristic based on the firing rate clamping closed loop of the present invention will be further described in conjunction with the accompanying drawings.

[0023] The neuron phase response characteristic measurement system based on the discharge rate clamping closed loop of the present invention includes a neuron discharge rate detection device 1 , a PID control device 2 and a pulse generation device 3 connected to each other.

[0024] The neuron discharge rate detection device 1 can detect the action potential moment in real time in the experiment, and calculate the discharge rate. The discharge rate detection device 1 includes three parts: neuron membrane potential recording electrode 4 and action potential online detector 5 respectively. And action potential frequency estimator 6; Described neuron membrane potential recording electrode 4 records the membrane potential of neuron, and is connected with action pote...

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Abstract

The invention provides a neuron phase response characteristic measuring system based on a discharge rate clamp closed loop. The system comprises a neuron discharge rate detection device, a PID control device and a pulse generation device which are mutually connected. The neuron phase response characteristic measuring system based on the discharge rate clamp closed loop has the advantages that according to the measuring system, by means of closed-loop control, the neuron discharge rate is maintained, the advantage of closed-loop electrophysiology is effectively utilized, measurement of multiple groups of phase response curves can be conveniently conducted by changing the discharge rate value, the accuracy of pulse stimulation time and phase positions is achieved, and important value is achieved for phase response experimental study.

Description

technical field [0001] The invention relates to biomedical engineering technology, in particular to a measurement system for the neuron phase response characteristic based on the firing rate clamping closed loop. Background technique [0002] The phase response curve is an experimentally measurable curve used to describe the response of neurons to small perturbations. It can be used as an indicator of the cell-level characteristics of neural network synchronization and can be used to infer network characteristics. In excitatory firing neurons, phase response curves quantify the effect of an extremely small depolarizing current pulse on the timing of successive action potentials. When cells discharge regularly, the stimulation pulse can advance or delay the next action potential moment, and the phase response curve describes the relationship between the phase of the added pulse and the phase shift caused by the pulse disturbance. Phase-response curves classify single-neuron ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/04
Inventor 魏熙乐司开利卢梅丽伊国胜王江邓斌于海涛
Owner TIANJIN UNIV
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