Photosensitive prodrug-containing amphiphilic polymer in main chain, preparation method and nanomicelle thereof
An amphiphilic polymer and photosensitive technology, applied in the field of nanomicelle, preparation, and main chain containing photosensitive prodrug amphiphilic polymer
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[0042] The present invention also provides a method for preparing amphiphilic polymers containing photosensitive prodrugs in the main chain, including the following steps:
[0043] Step 1: preparing a photoactive tetravalent platinum complex;
[0044] Step 2: reacting the photoactive tetravalent platinum complex obtained in step 1 with diisocyanate to obtain the first intermediate;
[0045] Step 3: React the first intermediate obtained in Step 2 with monomethyl ether polyethylene glycol to obtain an amphiphilic polymer containing a photosensitive prodrug in the main chain.
[0046] According to the present invention, the photoactive tetravalent platinum complex is first prepared, and the preparation method preferably includes:
[0047] ① put K 2 PtCl 4 React with the ligand to obtain the ligand compound;
[0048] ② The ligand compound obtained in ① and AgNO 3 , NaN 3 reaction, and then add H 2 o 2 reaction to obtain photoactive tetravalent platinum complexes.
[0049]...
Embodiment 1
[0063] Preparation K 2 PtCl 4 (400mg, 0.96mmol) in water, K 2 PtCl 4 The concentration is 10mg / mL, react with pyridine (303.74mg, 3.84mmol) at 75°C for 24h to generate pyridine compound; then add AgNO 3 (326.4mg, 1.92mmol), after reacting at 60°C for 4h, add 1.92mmol NaN 3 , at room temperature, stirring the reaction time 24h, then adding 4.8mmol H 2 o 2. , react at room temperature for 20 min, and purify the obtained product to obtain a photoactive tetravalent platinum complex.
[0064]
Embodiment 2
[0066] Preparation K 2 PtCl 4 (500mg, 1.2mmol) in water, K 2 PtCl 4 The concentration is 10mg / mL, react with pyridine (379.69mg, 4.8mg) at 75°C for 24h to generate pyridine compound; then add AgNO 3 (408mg, 2.4mmol), reacted at 60°C for 4h, then added 6mmol NaN 3 , at room temperature, stirring the reaction time 24h, then adding 6mmol H 2 o 2. , react at room temperature for 30 min, and purify the obtained product to obtain a photoactive tetravalent platinum complex.
[0067]
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