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Composition for treating acute stage of chronic pulmonary heart disease

A chronic cor pulmonale and composition technology, applied in the medical field, can solve problems such as protracted disease, high mortality rate, and respiratory failure, and achieve the effect of long duration of curative effect, good comprehensive effect, and wide selection range

Inactive Publication Date: 2015-12-23
戴礼礼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acute exacerbation of cor pulmonale is a clinically critical emergency, and the disease progresses rapidly. During the acute attack, hypoxia and hypercapnia stimulate the release of erythropoietin from the juxtaglomerular apparatus, which increases red blood cells and increases blood viscosity, which further hinders pulmonary circulation resistance. Respiratory failure can occur due to intractable respiratory and circulatory failure, which can easily lead to the death of patients. At present, there is no specific treatment for cor pulmonale, so the clinical mortality rate is still high, which not only seriously affects the quality of life of patients, It also has a great impact on the family and society
[0003] The effect of traditional conventional treatment is not ideal, the patient's condition is protracted, and has a high mortality rate. On the basis of conventional western medicine treatment, the application of traditional Chinese medicine to treat the root cause can take care of both symptoms and root causes, while reducing the amount of western medicine and reducing the risk of death. Toxic and side effects, complementary advantages, obvious effect

Method used

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  • Composition for treating acute stage of chronic pulmonary heart disease
  • Composition for treating acute stage of chronic pulmonary heart disease
  • Composition for treating acute stage of chronic pulmonary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Capsules

example 1

[0025] a.

[0026] Composition 200g

[0027] Blank pill core 200g

[0028] 7% PVP solution (solvent is 90% ethanol) 200g

[0029] Preparation process: the composition is passed through a 100-mesh sieve, and the axilimus is passed through a 120-mesh sieve, and the prescription amount is weighed and poured into a lower hopper. Turn on the granulation coating machine (Taiwan Yuancheng Machinery Factory), the inlet air pressure is 0.5bar, the inlet air temperature is 30℃, the spray gun pressure (CYL) is 3bar, the atomization pressure (CAP1) is 0.8bar, poured into the blank pellets, and granulated . The feeding speed is 4 rpm, the peristaltic pump is 12%, the rotating speed of the turntable is 145 rpm, and 7% PVP solution (solvent is 90% ethanol) is sprayed. At the end of granulation, it was dried at 50°C and discharged.

[0030] b. Preparation of the composition

[0031] The parts by weight of the described Chinese medicinal materials are as follows: 16 parts by weight of Ch...

example 2

[0034] a.

[0035] Composition 200g

[0036] Blank pill core 200g

[0037] 7% PVP solution (solvent is 90% ethanol) 200g

[0038] The preparation process is the same as that of Example 1.

[0039] B. the parts by weight of the described Chinese medicinal materials are as follows: 20 parts by weight of Chuanxiong, 16 parts by weight of Radix Paeoniae Alba, 10 parts by weight of Angelica sinensis, 10 parts by weight of Rhizoma Anemarrhena, 9 parts by weight of lotus leaf, 9 parts by weight of Forsythia suspensa, Tilia 10 parts by weight of licorice, 5 parts by weight of licorice, the amount of water added is 10 times the weight of the crude drug, the decocting time is 2 hours, decocted 2 times, and filtered; the filtrate was combined, left standing, and the supernatant was concentrated and dried to obtain .

[0040] c. Use a hard capsule medicine filling machine to fill the raw medicine according to the amount of 250mg in each capsule.

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Abstract

The invention belongs to the technical field of medicine, and relates to a composition for treating the acute stage of the chronic pulmonary heart disease. The composition is prepared from, by weight, rhizoma chuanxiong, pterocephalus hookeri heck, angelica sinensis, rhizoma anemarrhenae, lotus leaf, fructus forsythiae, semen lepidii and radix glycyrrhizae. The composition is good in comprehensive effect and convenient to use. The result obtained through clinical tests quite clearly shows that the composition can effectively treat the chronic pulmonary heart disease and has clinical popularization value.

Description

technical field [0001] The invention provides a composition for treating acute phase of chronic pulmonary heart disease, belonging to the technical field of medicine. Background technique [0002] Pulmonary heart disease is a common disease of the respiratory system. The prevalence of pulmonary heart disease in my country is about 4%, accounting for 38.5%-40% of hospitalized heart disease. Acute exacerbation of cor pulmonale is a clinically critical emergency. The disease progresses rapidly. In the acute exacerbation period, hypoxia and hypercapnia stimulate the release of erythropoietin from the paraglomerular apparatus, which increases red blood cells and increases blood viscosity, which further obstructs pulmonary circulation resistance. Intractable respiratory and circulatory failure can lead to respiratory failure, which can easily lead to death of patients. At present, there is no effective treatment method for pulmonary heart disease, so the clinical mortality rate i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P11/00
Inventor 戴礼礼
Owner 戴礼礼
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