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Application of nicotinamide adenine dinucleotide in preparation of drug for preventing and treating heart ischemic injuries

A technology of nicotinamide adenine and dinucleotide, which is applied in the fields of drug combination, cardiovascular system diseases, and pharmaceutical formulations, and can solve problems such as the application report of nicotinamide adenine dinucleotide that has not yet been reported.

Inactive Publication Date: 2015-12-23
SHANGHAI CHEST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the application of nicotinamide adenine dinucleotide in the preparation of drugs for the prevention and treatment of cardiac ischemic injury

Method used

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  • Application of nicotinamide adenine dinucleotide in preparation of drug for preventing and treating heart ischemic injuries
  • Application of nicotinamide adenine dinucleotide in preparation of drug for preventing and treating heart ischemic injuries
  • Application of nicotinamide adenine dinucleotide in preparation of drug for preventing and treating heart ischemic injuries

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Experimental program
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Embodiment Construction

[0012] The experimental content of the present invention on the application of nicotinamide adenine dinucleotide in the preparation of drugs for preventing myocardial ischemia injury mainly includes the following aspects:

[0013] 1. NAD+ has a protective effect on myocardial infarction caused by cardiac ischemia, can reduce infarct volume and lower the level of plasma troponin I.

[0014] 2. NAD+ has a protective effect on apoptosis caused by cardiac ischemia.

[0015] The following pharmacodynamic experiments further illustrate that NAD+ has an obvious therapeutic effect on myocardial ischemia injury caused by myocardial infarction.

[0016] 1. Experimental method

[0017] 1. Animal manipulation

[0018] Rats were used in the research, and the experimental animals were kept in the MED-X Research Institute of Shanghai Jiaotong University for animal experiments. All operating procedures are in compliance with the Shanghai Jiaotong University Laboratory Animal Protection and...

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PUM

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Abstract

The invention relates to application of nicotinamide adenine dinucleotide as an active ingredient in preparation of a drug for preventing or treating heart ischemic injuries. In experiments, caudal vein normal saline injection and a heart ischemia operation are carried out on rats in a control group, it is found through research results that a great number of apoptosis signals (TUNEL positive signals) appear on the hearts, while apoptosis signals of rats, on which caudal vein NAD+solution injection is carried out, in an experiment group can be effectively reduced.

Description

technical field [0001] The invention relates to the application of nicotinamide adenine dinucleotide in the field of pharmacy. More specifically, nicotinamide adenine dinucleotide (NAD for short) + ) in the preparation of drugs for the prevention or treatment of cardiac ischemic injury. Background technique [0002] The chemical structural formula of nicotinamide adenine dinucleotide is: [0003] . [0004] The preparation method of nicotinamide adenine dinucleotide mainly uses yeast as raw material, the yeast is extracted by boiling water, the crude product is acidified and precipitated with lead acetate, and the crude product is processed and refined by formic acid type cation exchange resin column. There is no report on the application of nicotinamide adenine dinucleotide in the preparation of drugs for the prevention and treatment of cardiac ischemic injury. Contents of the invention [0005] The object of the present invention is to propose the application of ni...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P9/10
Inventor 曲新凯殷卫海张佑俊
Owner SHANGHAI CHEST HOSPITAL
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